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Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis
المؤلفون المشاركون
Xiao, Bi-huan
Shi, Meihui
Chen, Hongqiang
Cui, Shaoshan
Wu, Yan
Chen, Hong-Duo
Gao, X.-H.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-27
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Abnormality of glutathione peroxidase (GPx) is involved in the etiology and pathogenesis of vitiligo.
However, the results were controversial.
Aim.
The purpose of this meta-analysis is to compare the levels of GPx between vitiligo patients and healthy controls.
Methods.
Relevant published articles were searched according to eligibility criteria.
A meta-analysis was conducted to pool estimates of the standardized mean difference (SMD) with 95% confidence interval (CI).
Results.
Twenty-three studies with a total of 1076 vitiligo patients and 770 healthy controls were included.
The pooled meta-analysis showed that patients with vitiligo had equivalent levels of GPx with the healthy controls (SMD = −0.47, 95% CI: −1.03 to 0.08, and p=0.095).
Further subgroup analysis showed that the GPx levels of Asian patients or segmental vitiligo patients were, respectively, lower than those of healthy controls (Asian: SMD = −0.47, 95% CI: −1.08 to 0.14, and p=0.001; segmental: SMD = −3.59, 95% CI: −6.38 to −0.80, and p=0.012).
Furthermore, the GPx levels in serum/plasma were significantly decreased in either stable or active vitiligo patients, comparing to healthy controls (stable: SMD = −2.01, 95% CI: −3.52 to −0.49, and p=0.009; active: SMD = −2.34, 95% CI: −4.07 to −0.61, and p=0.008).
Conclusion.
This meta-analysis showed a significant association between low GPx level and vitiligo.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xiao, Bi-huan& Shi, Meihui& Chen, Hongqiang& Cui, Shaoshan& Wu, Yan& Gao, X.-H.…[et al.]. 2016. Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xiao, Bi-huan…[et al.]. Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1097212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xiao, Bi-huan& Shi, Meihui& Chen, Hongqiang& Cui, Shaoshan& Wu, Yan& Gao, X.-H.…[et al.]. Glutathione Peroxidase Level in Patients with Vitiligo: A Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1097212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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