Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein
المؤلفون المشاركون
Hossain, Mohammad Uzzal
Khan, Md. Arif
Rakib-Uz-Zaman, S. M.
Ali, Mohammad Tuhin
Islam, Md. Saidul
Keya, Chaman Ara
Salimullah, Md.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-28
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders which can affect the quality of life severely.
Injectable insulin is currently being used to treat DM which is mainly associated with patient inconvenience.
Small molecules that can act as insulin receptor (IR) agonist would be better alternatives to insulin injection.
Herein, ten bioactive small compounds derived from Gymnema sylvestre (G.
sylvestre) were chosen to determine their IR binding affinity and ADMET properties using a combined approach of molecular docking study and computational pharmacokinetic elucidation.
Designing structural analogues were also performed for the compounds associated with toxicity and less IR affinity.
Among the ten parent compounds, six were found to have significant pharmacokinetic properties with considerable binding affinity towards IR while four compounds were associated with toxicity and less IR affinity.
Among the forty structural analogues, four compounds demonstrated considerably increased binding affinity towards IR and less toxicity compared with parent compounds.
Finally, molecular interaction analysis revealed that six parent compounds and four analogues interact with the active site amino acids of IR.
So this study would be a way to identify new therapeutics and alternatives to insulin for diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hossain, Mohammad Uzzal& Khan, Md. Arif& Rakib-Uz-Zaman, S. M. & Ali, Mohammad Tuhin& Islam, Md. Saidul& Keya, Chaman Ara…[et al.]. 2016. Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1097300
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hossain, Mohammad Uzzal…[et al.]. Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1097300
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hossain, Mohammad Uzzal& Khan, Md. Arif& Rakib-Uz-Zaman, S. M. & Ali, Mohammad Tuhin& Islam, Md. Saidul& Keya, Chaman Ara…[et al.]. Treating Diabetes Mellitus: Pharmacophore Based Designing of Potential Drugs from Gymnema sylvestre against Insulin Receptor Protein. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1097300
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097300
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر