Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay
المؤلفون المشاركون
Bodmer, Daniel
Brand, Yves
Leitmeyer, Katharina
Glutz, Andrea
Setz, Cristian
Wieland, Leonie
Egloff, Sulamith
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Statins are inhibitors of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase, an enzyme necessary for the production of mevalonate.
They are widely used as cholesterol-lowering drugs.
However, conflicting data about the effect of statins on neuronal cells has been published.
To explore the effect of simvastatin on spiral ganglion neurons (SGNs), SG explants of 5-day-old rats were treated with increasing concentrations of simvastatin.
In addition, SG explants were treated with mevalonate and with the combination of simvastatin and mevalonate.
SGN number, length of the neurites, area of nonneuronal supporting cells, and neuronal survival were analyzed.
Simvastatin treatment results in a significant dose-dependent decrease of SG neurite number, length of neurites, area of supporting cells, and SG neuronal survival compared to control.
Interestingly, treatment with mevalonate in addition to simvastatin increased SG neuronal survival compared to simvastatin treatment only.
However, treatment with mevalonate in addition to simvastatin did not influence SG neurite number, length of neurites, and area of supporting cells compared to simvastatin treatment only.
Our results suggest a neurotoxic effect of simvastatin on SGNs in vitro.
Neurotoxicity seems to be at least partially mediated by the mevalonate pathway.
Therefore, caution is warranted to use simvastatin as a potential otoprotective drug.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Leitmeyer, Katharina& Glutz, Andrea& Setz, Cristian& Wieland, Leonie& Egloff, Sulamith& Bodmer, Daniel…[et al.]. 2016. Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097372
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Leitmeyer, Katharina…[et al.]. Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097372
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Leitmeyer, Katharina& Glutz, Andrea& Setz, Cristian& Wieland, Leonie& Egloff, Sulamith& Bodmer, Daniel…[et al.]. Simvastatin Results in a Dose-Dependent Toxic Effect on Spiral Ganglion Neurons in an In Vitro Organotypic Culture Assay. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097372
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097372
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر