Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma
المؤلفون المشاركون
Zhou, Lin
Zhang, Lufei
He, Tianyu
Yan, Yingcai
Zhang, Yuan
Zhou, Xiaohu
Huang, Pengfei
Kong, Yang
Xie, Minjie
Zhang, Linshi
Sun, Qiang
Zhou, Dongkai
Wang, Weilin
Zheng, Shusen
Xie, Haiyang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-08
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Long noncoding RNAs (lncRNAs) play crucial roles in cancer occurrence and progression.
However, the relationship between the expression levels of lncRNAs and the hepatocellular carcinoma (HCC) process is unclear.
The goal of this study was to determine the expression level of ZNF674-AS1, a newly found lncRNA, in HCC and its clinical association.
The expression of ZNF674-AS1 in 137 pairs of tumorous and adjacent normal tissues from patients with HCC was detected by quantitative real-time reverse transcription polymerase chain reaction.
Additionally, the potential associations between its level in HCC tissue and clinicopathological features were analyzed.
The expression of ZNF674-AS1 in the HCC cell lines HepG2, HCCLM3, SK-Hep1, HuH7, Hep3B, and MHCC97H was significantly downregulated compared with that in the normal liver cell line QSG-7701.
The expression of ZNF674-AS1 was downregulated in 72% (99/137) of HCC tissues compared with that in paired adjacent normal tissues (p<0.01).
The results showed that the ZNF674-AS1 expression level was significantly correlated with metastasis (p=0.041), clinical stage (p=0.039), and histopathologic grading (p=0.045).
In addition, the Kaplan–Meier survival curves revealed that low ZNF674-AS1 expression was associated with poor prognosis in patients with HCC.
Our data suggest that ZNF674-AS1 may play some role during cancer occurrence and progression and may be a new biomarker for HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Lufei& He, Tianyu& Yan, Yingcai& Zhang, Yuan& Zhou, Xiaohu& Huang, Pengfei…[et al.]. 2016. Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097379
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Lufei…[et al.]. Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097379
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Lufei& He, Tianyu& Yan, Yingcai& Zhang, Yuan& Zhou, Xiaohu& Huang, Pengfei…[et al.]. Expression and Clinical Significance of the Novel Long Noncoding RNA ZNF674-AS1 in Human Hepatocellular Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097379
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097379
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر