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TNFα Affects Ciliary Beat Response to Increased Viscosity in Human Pediatric Airway Epithelium
المؤلفون المشاركون
González, Claudia
Droguett, Karla
Ríos, Mariana
Villalón, Manuel
Cohen, Noam A.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
In airway epithelium, mucociliary clearance (MCC) velocity depends on the ciliary beat frequency (CBF), and it is affected by mucus viscoelastic properties.
Local inflammation induces secretion of cytokines (TNFα) that can alter mucus viscosity; however airway ciliated cells have an autoregulatory mechanism to prevent the collapse of CBF in response to increase in mucus viscosity, mechanism that is associated with an increment in intracellular Ca+2 level (Ca2+i).
We studied the effect of TNFα on the autoregulatory mechanism that regulates CBF in response to increased viscosity using dextran solutions, in ciliated cells cultured from human pediatric epithelial adenoid tissue.
Cultures were treated with TNFα, before and after the viscous load was changed.
TNFα treatment produced a significantly larger decrease in CBF in cultures exposed to dextran.
Furthermore, an increment in Ca2+i was observed, which was significantly larger after TNFα treatment.
In conclusion, although TNFα has deleterious effects on ciliated cells in response to maintaining CBF after increasing viscous loading, it has a positive effect, since increasing Ca2+i may prevent the MCC collapse.
These findings suggest that augmented levels of TNFα associated with an inflammatory response of the nasopharyngeal epithelium may have dual effects that contribute to maintaining the effectiveness of MCC in the upper airways.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
González, Claudia& Droguett, Karla& Ríos, Mariana& Cohen, Noam A.& Villalón, Manuel. 2016. TNFα Affects Ciliary Beat Response to Increased Viscosity in Human Pediatric Airway Epithelium. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097391
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
González, Claudia…[et al.]. TNFα Affects Ciliary Beat Response to Increased Viscosity in Human Pediatric Airway Epithelium. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097391
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
González, Claudia& Droguett, Karla& Ríos, Mariana& Cohen, Noam A.& Villalón, Manuel. TNFα Affects Ciliary Beat Response to Increased Viscosity in Human Pediatric Airway Epithelium. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097391
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097391
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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