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Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models
المؤلفون المشاركون
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-16
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Contrast-induced acute kidney injury (CI-AKI) can occur in 3–25% of patients receiving radiocontrast material (RCM) despite appropriate preventive measures.
Often patients with an atherosclerotic vasculature have to receive large doses of RCM.
Thus, animal studies to uncover the exact pathomechanism of CI-AKI are needed.
Sensitive and specific histologic end-points are lacking; thus in the present review we summarize the histologic appearance of different rodent models of CI-AKI.
Single injection of RCM causes overt renal damage only in rabbits.
Rats and mice need an additional insult to the kidney to establish a clinically manifest CI-AKI.
In this review we demonstrate that the concentrating ability of the kidney may be responsible for species differences in sensitivity to CI-AKI.
The most commonly held theory about the pathomechanism of CI-AKI is tubular cell injury due to medullary hypoxia.
Thus, the most common additional insult in rats and mice is some kind of ischemia.
The histologic appearance is tubular epithelial cell (TEC) damage; however severe TEC damage is only seen if RCM is combined by additional ischemia.
TEC vacuolization is the first sign of CI-AKI, as it is a consequence of RCM pinocytosis and lysosomal fusion; however it is not sensitive as it does not correlate with renal function and is not specific as other forms of TEC damage also cause vacuolization.
In conclusion, histopathology alone is insufficient and functional parameters and molecular biomarkers are needed to closely monitor CI-AKI in rodent experiments.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kiss, Norbert& Hamar, Péter. 2016. Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models. BioMed Research International،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097427
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kiss, Norbert& Hamar, Péter. Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models. BioMed Research International No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1097427
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kiss, Norbert& Hamar, Péter. Histopathological Evaluation of Contrast-Induced Acute Kidney Injury Rodent Models. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1097427
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097427
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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