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Transneuronal Degeneration of Thalamic Nuclei following Middle Cerebral Artery Occlusion in Rats
المؤلفون المشاركون
Chang, Shu-Jen
Cherng, Juin-Hong
Wang, Ding-Han
Yu, Shu-Ping
Liou, Nien-Hsien
Hsu, Ming-Lun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-11
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
Postinfarction transneuronal degeneration refers to secondary neuronal death that occurs within a few days to weeks following the disruption of input or output to synapsed neurons sustaining ischemic insults.
The thalamus receives its blood supply from the posterior circulation; however, infarctions of the middle cerebral arterial may cause secondary transneuronal degeneration in the thalamus.
In this study, we presented the areas of ischemia and associated transneuronal degeneration following MCAo in a rat model.
Materials and Methods.
Eighteen 12-week-old male Sprague-Dawley rats were randomly assigned to receive middle cerebral artery occlusion surgery for 1, 7, and 14 days.
Cerebral atrophy was assessed by 2,3,5-triphenyltetrazolium hydrochloride staining.
Postural reflex and open field tests were performed prior to animal sacrifice to assess the effects of occlusion on behavior.
Results.
Myelin loss was observed at the lesion site following ischemia.
Gliosis was also observed in thalamic regions 14 days following occlusion.
Differential degrees of increased vascular endothelial growth factor expression were observed at each stage of infarction.
Increases in myelin basic protein levels were also observed in the 14-day group.
Conclusion.
The present rat model of ischemia provides evidence of transneuronal degeneration within the first 14 days of occlusion.
The observed changes in protein expression may be associated with self-repair mechanisms in the damaged brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chang, Shu-Jen& Cherng, Juin-Hong& Wang, Ding-Han& Yu, Shu-Ping& Liou, Nien-Hsien& Hsu, Ming-Lun. 2016. Transneuronal Degeneration of Thalamic Nuclei following Middle Cerebral Artery Occlusion in Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097470
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chang, Shu-Jen…[et al.]. Transneuronal Degeneration of Thalamic Nuclei following Middle Cerebral Artery Occlusion in Rats. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097470
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chang, Shu-Jen& Cherng, Juin-Hong& Wang, Ding-Han& Yu, Shu-Ping& Liou, Nien-Hsien& Hsu, Ming-Lun. Transneuronal Degeneration of Thalamic Nuclei following Middle Cerebral Artery Occlusion in Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097470
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097470
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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