Identifying the Types of Ion Channel-Targeted Conotoxins by Incorporating New Properties of Residues into Pseudo Amino Acid Composition
المؤلفون المشاركون
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-18
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Conotoxins are a kind of neurotoxin which can specifically interact with potassium, sodium type, and calcium channels.
They have become potential drug candidates to treat diseases such as chronic pain, epilepsy, and cardiovascular diseases.
Thus, correctly identifying the types of ion channel-targeted conotoxins will provide important clue to understand their function and find potential drugs.
Based on this consideration, we developed a new computational method to rapidly and accurately predict the types of ion-targeted conotoxins.
Three kinds of new properties of residues were proposed to use in pseudo amino acid composition to formulate conotoxins samples.
The support vector machine was utilized as classifier.
A feature selection technique based on F-score was used to optimize features.
Jackknife cross-validated results showed that the overall accuracy of 94.6% was achieved, which is higher than other published results, demonstrating that the proposed method is superior to published methods.
Hence the current method may play a complementary role to other existing methods for recognizing the types of ion-target conotoxins.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Yun& Zheng, Yufei& Tang, Hua. 2016. Identifying the Types of Ion Channel-Targeted Conotoxins by Incorporating New Properties of Residues into Pseudo Amino Acid Composition. BioMed Research International،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097591
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Yun…[et al.]. Identifying the Types of Ion Channel-Targeted Conotoxins by Incorporating New Properties of Residues into Pseudo Amino Acid Composition. BioMed Research International No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1097591
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Yun& Zheng, Yufei& Tang, Hua. Identifying the Types of Ion Channel-Targeted Conotoxins by Incorporating New Properties of Residues into Pseudo Amino Acid Composition. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1097591
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097591
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر