Clinical Outcome and Prognostic Factors of Intensity-Modulated Radiotherapy for T4 Stage Nasopharyngeal Carcinoma
المؤلفون المشاركون
Luo, Yangkun
Gao, Yang
Yang, Guangquan
Lang, Jinyi
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-19
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Objective.
To analyze the clinical outcomes and prognostic factors of intensity-modulated radiotherapy (IMRT) for T4 stage nasopharyngeal carcinoma (NPC).
Methods.
Between March 2005 and March 2010, 110 patients with T4 stage NPC without distant metastases were treated.
All patients received IMRT.
Induction and/or concurrent chemotherapy were given.
47 (42.7%) patients received IMRT replanning.
Results.
The 5-year local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), distant metastasis-free survival (DMFS), progression-free survival (PFS), and overall survival (OS) rates were 90.1%, 97.0%, 67.5%, 63.9%, and 64.5%, respectively.
Eleven patients experienced local-regional failure and total distant metastasis occurred in 34 patients.
45 patients died and 26 patients died of distant metastasis alone.
The 5-year LRFS rates were 97.7% and 83.8% for the patients that received and did not receive IMRT replanning, respectively ( P = 0.023 ).
Metastasis to the retropharyngeal lymph nodes (RLN) was associated with inferior 5-year OS rate (61.0% versus 91.7%, P = 0.034 ).
The gross tumor volume of the right/left lymph nodes (GTVln) was an independent prognostic factor for DMFS ( P = 0.006 ) and PFS ( P = 0.018 ).
GTVln was with marginal significance as the prognostic factor for OS ( P = 0 .
050 ).
Conclusion.
IMRT provides excellent local-regional control for T4 stage NPC.
Benefit of IMRT replanning may be associated with improvement in local control.
Incorporating GTVln into the N staging system may provide better prognostic information.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Yangkun& Gao, Yang& Yang, Guangquan& Lang, Jinyi. 2016. Clinical Outcome and Prognostic Factors of Intensity-Modulated Radiotherapy for T4 Stage Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097792
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Yangkun…[et al.]. Clinical Outcome and Prognostic Factors of Intensity-Modulated Radiotherapy for T4 Stage Nasopharyngeal Carcinoma. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1097792
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Yangkun& Gao, Yang& Yang, Guangquan& Lang, Jinyi. Clinical Outcome and Prognostic Factors of Intensity-Modulated Radiotherapy for T4 Stage Nasopharyngeal Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1097792
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097792
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر