Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts
المؤلفون المشاركون
Sacco, Anna Maria
Montagnani, Stefania
Arcucci, Alessandro
Ruocco, Maria Rosaria
Granato, Giuseppina
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-09
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Redox balance is associated with the regulation of several cell signalling pathways and functions.
In fact, under physiological conditions, cells maintain a balance between oxidant and antioxidant systems, and reactive oxygen species (ROS) can act as second messengers to regulate cell proliferation, cell death, and other physiological processes.
Cancer tissues usually contain higher levels of ROS than normal tissues, and this ROS overproduction is associated with tumor development.
Neoplastic tissues are very heterogeneous systems, composed of tumor cells and microenvironment that has a critical role in tumor progression.
Cancer associated fibroblasts (CAFs) represent the main cell type of tumor microenvironment, and they contribute to tumor growth by undergoing an irreversible activation process.
It is known that ROS can be transferred from cancer cells to fibroblasts.
In particular, ROS affect the behaviour of CAFs by promoting the conversion of fibroblasts to myofibroblasts that support tumor progression and dissemination.
Furthermore, the wrecking of redox homeostasis in cancer cells and tumor microenvironment induces a metabolic reprogramming in tumor cells and cancer associated fibroblasts, giving advantage to cancer growth.
This review describes the role of ROS in tumor growth, by focusing on CAFs activation and metabolic interactions between cancer cells and stromal fibroblasts.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Arcucci, Alessandro& Ruocco, Maria Rosaria& Granato, Giuseppina& Sacco, Anna Maria& Montagnani, Stefania. 2016. Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097796
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Arcucci, Alessandro…[et al.]. Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1097796
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Arcucci, Alessandro& Ruocco, Maria Rosaria& Granato, Giuseppina& Sacco, Anna Maria& Montagnani, Stefania. Cancer: An Oxidative Crosstalk between Solid Tumor Cells and Cancer Associated Fibroblasts. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1097796
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097796
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر