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A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation
المؤلفون المشاركون
Labra, Massimo
Ferri, Emanuele
Manfrini, Enrico
Sandionigi, Anna
La Ferla, Barbara
Schiano, Irene
Michelotti, Angela
Nobile, Vincenzo
Di Gennaro, Patrizia
Mezzasalma, Valerio
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-09
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background and Aim.
The efficacy of supplementation treatment with two multispecies probiotic formulates on subjects diagnosed with IBS-C and the assessment of their gut microbiota were investigated.
Methods.
A randomized, double-blind, three-arm parallel group trial was carried out on 150 IBS-C subjects divided into three groups (F_1, F_2, and F_3).
Each group received a daily oral administration of probiotic mixtures (for 60 days) F_1 or F_2 or placebo F_3, respectively.
Fecal microbiological analyses were performed by species-specific qPCR to assess the different amount of probiotics.
Results.
The percentage of responders for each symptom was higher in the probiotic groups when compared to placebo group during the treatment period ( t 60 ) and was maintained quite similar during the follow-up period ( t 90 ).
Fecal analysis demonstrated that probiotics of the formulations increased during the times of treatment only in fecal DNA from subjects treated with F_1 and F_2 and not with F_3, and the same level was maintained during the follow-up period.
Conclusions.
Multispecies probiotic supplementations are effective in IBS-C subjects and induce a different assessment in the composition of intestinal microbiota.
This clinical study is registered with the clinical study registration number ISRCTN15032219.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mezzasalma, Valerio& Manfrini, Enrico& Ferri, Emanuele& Sandionigi, Anna& La Ferla, Barbara& Schiano, Irene…[et al.]. 2016. A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097882
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mezzasalma, Valerio…[et al.]. A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1097882
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mezzasalma, Valerio& Manfrini, Enrico& Ferri, Emanuele& Sandionigi, Anna& La Ferla, Barbara& Schiano, Irene…[et al.]. A Randomized, Double-Blind, Placebo-Controlled Trial: The Efficacy of Multispecies Probiotic Supplementation in Alleviating Symptoms of Irritable Bowel Syndrome Associated with Constipation. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1097882
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1097882
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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