Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance
المؤلفون المشاركون
Chen, Jing
Zhang, Jiakui
Li, Xin
Zhang, Chundong
Zhang, Hongbin
Jin, Junzhe
Dai, Dongqiu
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
A disintegrin and metallopeptidase with thrombospondin motif type 8 (ADAMTS8), a member of the ADAMTS family, was discovered as a novel angiogenesis inhibitor.
We analyzed the expression and methylation of ADAMTS8 in primary gastric tumors and gastric cancer cell lines.
We also examined the relationship between ADAMTS8 expression and methylation and clinicopathologic features.
The results showed that the significant downregulation of ADAMTS8 mRNA expression was observed in gastric cancer cell lines and tissues, and its expression was related to invasive depth and lymph node metastasis.
CpG was hypermethylated in gastric cancer cell lines MKN45, MGC803, and BGC823, as well as primary gastric cancer specimens.
ADAMTS8 mRNA expression was significantly lower in methylated primary gastric tumors.
A significant association was found between ADAMTS8 methylation status and lymph node metastasis in primary gastric cancer.
Moreover, ADAMTS8 expression was upregulated in the gastric cancer cell lines MGC803, BGC823, and MKN45 after treatment with 5-aza-2′-deoxycytidine.
Thus, our results demonstrate that expression of ADAMTS8 mRNA is significantly decreased and DNA methylation is frequent in gastric cancer.
ADAMTS8 hypermethylation is associated with decreased expression in gastric cancer and may play an important role in the invasion and metastasis of gastric cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Jing& Zhang, Jiakui& Li, Xin& Zhang, Chundong& Zhang, Hongbin& Jin, Junzhe…[et al.]. 2016. Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098003
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Jing…[et al.]. Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098003
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Jing& Zhang, Jiakui& Li, Xin& Zhang, Chundong& Zhang, Hongbin& Jin, Junzhe…[et al.]. Downregulation of ADAMTS8 by DNA Hypermethylation in Gastric Cancer and Its Clinical Significance. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098003
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098003
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر