Relationship between Antibody Levels, IgG Binding to Plasmodium falciparum-Infected Erythrocytes, and Disease Outcome in Hospitalized Urban Malaria Patients from Dakar, Sénégal
المؤلفون المشاركون
Mbengue, Babacar
Fall, Mouhamadou Mansour
Sylla Niang, Maguette
Niang, Birahim
Varela, Marie Louise
Diatta, Antoine Marie
Mbow, Moustapha
Ndiaye, Kantome
Ndiaye Diallo, Rokhaya
Dieye, Alioune
Perraut, Ronald
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-03
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Management of clinical malaria requires the development of reliable diagnostic methods and efficient biomarkers for follow-up of patients.
Protection is partly based on IgG responses to parasite antigens exposed at the surface of infected erythrocytes (iRBCs).
These IgG responses appeared low during clinical infection, particularly in severe disease.
Methods.
We analyzed the IgG binding capacity to the surface of live erythrocytes infected by knob positive FCR3 strain.
Sera from 69 cerebral malaria (CM) and 72 mild malaria (MM) cases were analyzed by ELISA for IgG responses to five antigens from iRBC and by flow cytometry for IgG binding as expressed in labeling index ratio (LIR).
The relationship between IgG levels, LIR, parasitemia, age, and the clinical outcomes was evaluated.
Results.
We found a significant decrease of LIR in adult CM fatal cases compared to surviving patients (p=0.019).
In MM, LIRs were correlated to IgG anti-iRBC and anti-PfEMP3/5 levels.
In CM, no correlation was found between LIR, IgG levels, and parasitemia.
Conclusion.
The IgG binding assay was able to discriminate outcome of cerebral malaria cases and it deserves further development as a potential functional-associated assay for symptomatic malaria analysis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mbengue, Babacar& Fall, Mouhamadou Mansour& Sylla Niang, Maguette& Niang, Birahim& Varela, Marie Louise& Diatta, Antoine Marie…[et al.]. 2016. Relationship between Antibody Levels, IgG Binding to Plasmodium falciparum-Infected Erythrocytes, and Disease Outcome in Hospitalized Urban Malaria Patients from Dakar, Sénégal. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098104
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mbengue, Babacar…[et al.]. Relationship between Antibody Levels, IgG Binding to Plasmodium falciparum-Infected Erythrocytes, and Disease Outcome in Hospitalized Urban Malaria Patients from Dakar, Sénégal. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098104
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mbengue, Babacar& Fall, Mouhamadou Mansour& Sylla Niang, Maguette& Niang, Birahim& Varela, Marie Louise& Diatta, Antoine Marie…[et al.]. Relationship between Antibody Levels, IgG Binding to Plasmodium falciparum-Infected Erythrocytes, and Disease Outcome in Hospitalized Urban Malaria Patients from Dakar, Sénégal. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098104
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098104
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر