Radiation-Guided Peptide Delivery in a Mouse Model of Nasopharyngeal Carcinoma
المؤلفون المشاركون
Lin, Pei-cheng
He, Jun-yan
Le, Yu-yin
Du, Kai-xin
Zhu, Wei-feng
Peng, Qing-qin
Dong, Ya-ping
Li, Jin-luan
Wu, Jun-xin
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-21
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
This study aimed to evaluate the characteristics of the HVGGSSV peptide, exploring radiation-guided delivery in a mouse model of nasopharyngeal carcinoma.
Methods.
Mice with CNE-1 nasopharyngeal carcinoma were assigned to two different groups treated with Cy7-NHS and Cy7-HVGGSSV, respectively.
Meanwhile, each mouse received a single dose of 3 Gy radiation.
Biological distribution of the recombinant peptide was assessed on an in vivo small animal imaging system.
Results.
The experimental group showed maximum fluorescence intensity in irradiated tumors treated with Cy7-labeled HVGGSSV, while untreated (0 Gy) control tumors showed lower intensity levels.
Fluorescence intensities of tumors in the right hind limbs of experimental animals were 7.84×107±1.13×107, 1.35×108±2.66×107, 4.05×108±1.75×107, 5.57×108±3.47×107, and 9.26×107±1.73×107 photons/s/cm2 higher compared with left hind limb values at 1, 2, 15, 24, and 48 h, respectively.
Fluorescence intensities of tumor in the right hind limbs of the experimental group were 1.66×108±1.71×107, 1.51×108±3.23×107, 5.38×108±1.96×107, 5.89×108±3.57×107, and 1.62×108±1.69×107 photons/s/cm2 higher compared with control group values at 1, 2, 15, 24, and 48 h, respectively.
Fluorescence was not specifically distributed in the control group.
Compared with low fluorescence intensity in the heart, lungs, and tumors, high fluorescence distribution was found in the liver and kidney at 48 h.
Conclusions.
HVGGSSV was selectively bound to irradiated nasopharyngeal carcinoma, acting as a targeting transport carrier for radiation-guided drugs that are mainly metabolized in the kidney and liver.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lin, Pei-cheng& He, Jun-yan& Le, Yu-yin& Du, Kai-xin& Zhu, Wei-feng& Peng, Qing-qin…[et al.]. 2016. Radiation-Guided Peptide Delivery in a Mouse Model of Nasopharyngeal Carcinoma. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098105
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lin, Pei-cheng…[et al.]. Radiation-Guided Peptide Delivery in a Mouse Model of Nasopharyngeal Carcinoma. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098105
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lin, Pei-cheng& He, Jun-yan& Le, Yu-yin& Du, Kai-xin& Zhu, Wei-feng& Peng, Qing-qin…[et al.]. Radiation-Guided Peptide Delivery in a Mouse Model of Nasopharyngeal Carcinoma. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098105
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098105
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر