Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition

المؤلفون المشاركون

Yan, Zuo-qin
Qian, Ruizhe
Zhu, Zhu
Hua, Bingxuan
Shang, Zhanxian
Yuan, Gongsheng
Xu, Lirong
Li, Ermin
Sun, Ning
Lu, Chao
Li, Xiaobo

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-08-18

دولة النشر

مصر

عدد الصفحات

14

التخصصات الرئيسية

الطب البشري

الملخص EN

Background.

The risk of atherosclerosis is elevated in abnormal lipid metabolism and circadian rhythm disorder.

We investigated whether abnormal lighting condition would have influenced the circadian expression of clock genes and clock-controlled lipid metabolism-related genes in ApoE-KO mice.

Methods.

A mouse model of atherosclerosis with circadian clock genes expression disorder was established using ApoE-KO mice (ApoE-KO LD/DL mice) by altering exposure to light.

C57 BL/6J mice (C57 mice) and ApoE-KO mice (ApoE-KO mice) exposed to normal day and night and normal diet served as control mice.

According to zeitgeber time samples were acquired, to test atheromatous plaque formation, serum lipids levels and rhythmicity, clock genes, and lipid metabolism-related genes along with Sirtuin 1 (Sirt1) levels and rhythmicity.

Results.

Atherosclerosis plaques were formed in the aortic arch of ApoE-KO LD/DL mice.

The serum lipids levels and oscillations in ApoE-KO LD/DL mice were altered, along with the levels and diurnal oscillations of circadian genes, lipid metabolism-associated genes, and Sirt1 compared with the control mice.

Conclusions.

Abnormal exposure to light aggravated plaque formation and exacerbated disorders of serum lipids and clock genes, lipid metabolism genes and Sirt1 levels, and circadian oscillation.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhu, Zhu& Hua, Bingxuan& Shang, Zhanxian& Yuan, Gongsheng& Xu, Lirong& Li, Ermin…[et al.]. 2016. Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition. BioMed Research International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098119

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhu, Zhu…[et al.]. Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition. BioMed Research International No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1098119

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhu, Zhu& Hua, Bingxuan& Shang, Zhanxian& Yuan, Gongsheng& Xu, Lirong& Li, Ermin…[et al.]. Altered Clock and Lipid Metabolism-Related Genes in Atherosclerotic Mice Kept with Abnormal Lighting Condition. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1098119

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1098119