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Evaluation of Potential Clinical Surrogate Markers of a Trauma Induced Alteration of Clotting Factor Activities
المؤلفون المشاركون
Kauther, M. D.
Lendemans, S.
Schoeneberg, Carsten
Burggraf, Manuel
Payas, Arzu
Wegner, Alexander
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-28
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
The aim of this study was to identify routinely available clinical surrogate markers for potential clotting factor alterations following multiple trauma.
Methods.
In 68 patients admitted directly from the scene of the accident, all soluble clotting factors were analyzed and clinical data was collected prospectively.
Ten healthy subjects served as control group.
Results.
Patients showed reduced activities of clotting factors II, V, VII, and X and calcium levels (all P < 0.0001 to 0.01).
Levels of hemoglobin and base deficit correlated moderately to highly with the activities of a number of clotting factors.
Nonsurvivors and patients who needed preclinical intubation or hemostatic therapy showed significantly reduced factor activities at admission.
In contrast, factor VIII activity was markedly elevated after injury in general ( P < 0.0001 ), but reduced in nonsurvivors ( P < 0.05 ).
Conclusions.
Multiple trauma causes an early reduction of the activities of nearly all soluble clotting factors in general.
Initial hemoglobin and, with certain qualifications, base deficit levels demonstrated a potential value in detecting those underlying clotting factor deficiencies.
Nevertheless, their role as triggers of a hemostatic therapy as well as the observed response of factor VIII to multiple trauma and also its potential prognostic value needs further evaluation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Burggraf, Manuel& Payas, Arzu& Schoeneberg, Carsten& Wegner, Alexander& Kauther, M. D.& Lendemans, S.. 2016. Evaluation of Potential Clinical Surrogate Markers of a Trauma Induced Alteration of Clotting Factor Activities. BioMed Research International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098151
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Burggraf, Manuel…[et al.]. Evaluation of Potential Clinical Surrogate Markers of a Trauma Induced Alteration of Clotting Factor Activities. BioMed Research International No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1098151
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Burggraf, Manuel& Payas, Arzu& Schoeneberg, Carsten& Wegner, Alexander& Kauther, M. D.& Lendemans, S.. Evaluation of Potential Clinical Surrogate Markers of a Trauma Induced Alteration of Clotting Factor Activities. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1098151
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098151
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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