![](/images/graphics-bg.png)
Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis
المؤلفون المشاركون
Hong, Sung Hoo
Chung, Jinsoo
Byun, Seok-Soo
Hwang, Eu Chang
Kang, Seok Ho
Kwon, Tae Gyun
Kim, Hyeon Hoe
Kwak, Cheol
Kim, Yong-June
Lee, Won Ki
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-06
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in nonmetastatic renal cell carcinoma (non-mRCC) is controversial, although NLR has been established as a prognostic factor in several cancers.
The objective of our study was to assess the prognostic significance of preoperative NLR in non-mRCC, based on a large, multicenter cohort analysis.
Methods.
Totally, 1,284 non-mRCC patients undergoing surgery were enrolled from six institutions between 2000 and 2014.
Recurrence-free survival (RFS) and cancer-specific survival (CSS) were calculated, and the prognostic significance of NLR was evaluated.
Results.
Patients with higher NLR had larger tumors (p<0.001), higher T stage (p<0.001), worse Eastern Cooperative Oncology Group performance status (p<0.001), worse symptoms (p=0.003), sarcomatoid differentiation (p=0.004), and tumor necrosis (p<0.001).
The 5-year RFS and CSS rates were significantly lower in patients with high NLR than in those with low NLR (each p<0.001).
Multivariate analysis identified NLR to be an independent predictor of RFS and CSS (each p<0.05).
Moreover, predictive accuracy of multivariate models for RFS and CSS increased by 2.2% and 4.2%, respectively, with NLR inclusion.
Conclusions.
Higher NLR was associated with worse clinical behavior of non-mRCC.
Also, NLR was a significant prognostic factor of both RFS and CSS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Byun, Seok-Soo& Hwang, Eu Chang& Kang, Seok Ho& Hong, Sung Hoo& Chung, Jinsoo& Kwon, Tae Gyun…[et al.]. 2016. Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098156
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Byun, Seok-Soo…[et al.]. Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098156
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Byun, Seok-Soo& Hwang, Eu Chang& Kang, Seok Ho& Hong, Sung Hoo& Chung, Jinsoo& Kwon, Tae Gyun…[et al.]. Prognostic Significance of Preoperative Neutrophil-to-Lymphocyte Ratio in Nonmetastatic Renal Cell Carcinoma: A Large, Multicenter Cohort Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098156
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098156
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)