Development of a Regenerative Peripheral Nerve Interface for Control of a Neuroprosthetic Limb
المؤلفون المشاركون
Urbanchek, Melanie G.
Kung, Theodore A.
Frost, Christopher M.
Martin, David C.
Larkin, Lisa M.
Wollstein, Adi
Cederna, Paul S.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-17
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The purpose of this experiment was to develop a peripheral nerve interface using cultured myoblasts within a scaffold to provide a biologically stable interface while providing signal amplification for neuroprosthetic control and preventing neuroma formation.
Methods.
A Regenerative Peripheral Nerve Interface (RPNI) composed of a scaffold and cultured myoblasts was implanted on the end of a divided peroneal nerve in rats ( n = 25 ).
The scaffold material consisted of either silicone mesh, acellular muscle, or acellular muscle with chemically polymerized poly(3,4-ethylenedioxythiophene) conductive polymer.
Average implantation time was 93 days.
Electrophysiological tests were performed at endpoint to determine RPNI viability and ability to transduce neural signals.
Tissue samples were examined using both light microscopy and immunohistochemistry.
Results.
All implanted RPNIs, regardless of scaffold type, remained viable and displayed robust vascularity.
Electromyographic activity and stimulated compound muscle action potentials were successfully recorded from all RPNIs.
Physiologic efferent motor action potentials were detected from RPNIs in response to sensory foot stimulation.
Histology and transmission electron microscopy revealed mature muscle fibers, axonal regeneration without neuroma formation, neovascularization, and synaptogenesis.
Desmin staining confirmed the preservation and maturation of myoblasts within the RPNIs.
Conclusions.
RPNI demonstrates significant myoblast maturation, innervation, and vascularization without neuroma formation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Urbanchek, Melanie G.& Kung, Theodore A.& Frost, Christopher M.& Martin, David C.& Larkin, Lisa M.& Wollstein, Adi…[et al.]. 2016. Development of a Regenerative Peripheral Nerve Interface for Control of a Neuroprosthetic Limb. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098178
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Urbanchek, Melanie G.…[et al.]. Development of a Regenerative Peripheral Nerve Interface for Control of a Neuroprosthetic Limb. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098178
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Urbanchek, Melanie G.& Kung, Theodore A.& Frost, Christopher M.& Martin, David C.& Larkin, Lisa M.& Wollstein, Adi…[et al.]. Development of a Regenerative Peripheral Nerve Interface for Control of a Neuroprosthetic Limb. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098178
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098178
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر