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The Significance of Long Noncoding RNA H19 in Predicting Progression and Metastasis of Cancers: A Meta-Analysis
المؤلفون المشاركون
Jing, Wei
Zhu, Man
Zhang, Xian-wei
Pan, Zhong-ya
Gao, Shan-shan
Zhou, Hu
Qiu, Shi-li
Liang, Chun-zi
Tu, Jian-cheng
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-08
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Recently, numerous studies indicate that H19 plays a key role in tumorigenesis, but the results have been disputed, especially in the aspects of tumor progression and metastasis.
Therefore, we performed this meta-analysis to systematically summarize the relationship between H19 and cancers.
We searched PubMed, the Cochrane Library, CNKI, and Chinese Wan Fang to identify eligible studies.
Odds ratios and 95% confidence intervals were calculated to assess the effect size.
A total of 13 studies were enrolled in this meta-analysis, which was performed by Revman5.3 and Stata11.0 software.
Our meta-analysis showed that the expression of H19 was associated with distant metastasis in nongastrointestinal tumors (OR = 3.85, 95% CI = 1.31–11.36, P = 0.01 ) and, in gastrointestinal tumors (OR = 0.34, 95% CI = 0.15–0.78, P = 0.01 ), lymph node metastasis (OR = 2.04, 95% CI = 1.19–3.48, P = 0.009 ).
Moreover, in gastric cancer, H19 expression was significantly related to histological grade (OR = 0.50, 95% CI = 0.29–0.86, P = 0.01 ), TNM stage (OR = 0.19, 95% CI = 0.11–0.33, P < 0.01 ), and tumor invasion depth (OR = 0.11, 95% CI = 0.04–0.27, P < 0.01 ).
Therefore, H19 could serve as a potential marker for progression and metastasis evaluation of cancers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jing, Wei& Zhu, Man& Zhang, Xian-wei& Pan, Zhong-ya& Gao, Shan-shan& Zhou, Hu…[et al.]. 2016. The Significance of Long Noncoding RNA H19 in Predicting Progression and Metastasis of Cancers: A Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098252
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jing, Wei…[et al.]. The Significance of Long Noncoding RNA H19 in Predicting Progression and Metastasis of Cancers: A Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098252
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jing, Wei& Zhu, Man& Zhang, Xian-wei& Pan, Zhong-ya& Gao, Shan-shan& Zhou, Hu…[et al.]. The Significance of Long Noncoding RNA H19 in Predicting Progression and Metastasis of Cancers: A Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098252
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098252
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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