Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice
المؤلفون المشاركون
Yu, Wei hua
Zhao, Nan
Gu, Min
Yang, Wenxiu
Zhang, Man
Tian, Qi
Ru, Liyan
Lü, Yang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-18
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Dry skin pruritus is common in the elderly.
Recent reports show that T-cell signal path is involved in dry skin pruritus.
Zeta-chain-associated protein kinase 70 (ZAP70), as a T-cell receptor, may induce interleukin 2 (IL-2) secretion and promote nerve growth factor (NGF) secretion in skin.
This study aimed to detect the alteration of ZAP70 in a mice model with dry skin pruritus.
The C57BL mice with 5 months and 22 months were used as experimental animal.
Following a 5-day period of treatment of back with a mixture of acetone-diethyl-ether-water (AEW), mice exhibited a significant increase in spontaneous scratching behavior directed to the treated back compared to control animals in which back was similarly treated with water only (W).
After AEW process, spontaneous scratching in 22-month AEW mice was increased compared to 5-month AEW mice.
Western blot and real-time quantitative PCR data analysis showed that ZAP70 expression was significantly increased in 22-month AEW mice compared with 5-month AEW mice.
ELISA data showed that secretions of IL-2 and NGF in 22-month AEW mice were higher than 5-month AEW mice.
Our results indicate that increased ZAP70 is involved in dry skin in elderly pruritus.
Increased secretion of IL-2 and NGF may induce dry skin itch.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhao, Nan& Gu, Min& Yang, Wenxiu& Zhang, Man& Tian, Qi& Ru, Liyan…[et al.]. 2016. Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098350
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhao, Nan…[et al.]. Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098350
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhao, Nan& Gu, Min& Yang, Wenxiu& Zhang, Man& Tian, Qi& Ru, Liyan…[et al.]. Increased ZAP70 Is Involved in Dry Skin Pruritus in Aged Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098350
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098350
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر