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Altered Expression of TLR2 and TLR4 on Peripheral CD14+ Blood Monocytes in Children with Urinary Tract Infection
المؤلفون المشاركون
Pavlitou-Tsiontsi, Aikaterini
Papadopoulou-Alataki, Efimia
Eboriadou, Maria
Karananou, Panagiota
Fleva, Alexandra
Tramma, Despoina
Alataki, Anastasia
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Urinary tract infection (UTI) is the second most common bacterial infection, after otitis media, in infants and children.
The mechanisms of disease susceptibility and the role of immunity in the pathogenesis of UTI in children have been evaluated.
In recent years, Toll-Like Receptors (TLRs) have been recognized as specific components of the innate immune system constituting important mediators in host immune recognition.
The aim of the present study was to determine ΤLR2 and TLR4 expression during the acute phase of UTI in infants and children by measuring the CD14/TLR2 and CD14/TLR4 expression on monocytes.
We also attempted to compare the TLRs expression with the immunological status of the patients to healthy children.
The study group consisted of 60 children (36 females and 24 males) and the control group included 60 age-matched pediatric subjects (27 females and 33 males).
In our study, no antibody deficiency was found either in the children with UTI or in healthy subjects.
There might be a connection between low IgA, IgG, and IgG subclasses serum levels and UTI as there was a statistically significant difference between patients and healthy children.
A higher expression of CD14/TLR2 was revealed in patients (90,07%) compared to controls (85,48%) as well as CD14/TLR4 in patients (90,53%) compared to controls (87,25%) (statistically significant difference, p < 0,05 ).
The results of this study could provide new understanding of UTIs’ pathogenesis in children.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Karananou, Panagiota& Fleva, Alexandra& Tramma, Despoina& Alataki, Anastasia& Pavlitou-Tsiontsi, Aikaterini& Eboriadou, Maria…[et al.]. 2016. Altered Expression of TLR2 and TLR4 on Peripheral CD14+ Blood Monocytes in Children with Urinary Tract Infection. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098357
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Karananou, Panagiota…[et al.]. Altered Expression of TLR2 and TLR4 on Peripheral CD14+ Blood Monocytes in Children with Urinary Tract Infection. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098357
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Karananou, Panagiota& Fleva, Alexandra& Tramma, Despoina& Alataki, Anastasia& Pavlitou-Tsiontsi, Aikaterini& Eboriadou, Maria…[et al.]. Altered Expression of TLR2 and TLR4 on Peripheral CD14+ Blood Monocytes in Children with Urinary Tract Infection. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098357
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098357
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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