Early Developmental Low-Dose Methylmercury Exposure Alters Learning and Memory in Periadolescent but Not Young Adult Rats
المؤلفون المشاركون
Acosta-Saavedra, Leonor C.
Calderón-Aranda, Emma S.
Albores-García, Damaris
Hernandez, Alberto J.
Loera, Miriam J.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Few studies have assessed the effects of developmental methylmercury (MeHg) exposure on learning and memory at different ages.
The possibility of the amelioration or worsening of the effects has not been sufficiently investigated.
This study aimed to assess whether low-dose MeHg exposure in utero and during suckling induces differential disturbances in learning and memory of periadolescent and young adult rats.
Four experimental groups of pregnant Sprague-Dawley rats were orally exposed to MeHg or vehicle from gestational day 5 to weaning: (1) control (vehicle), (2) 250 μg/kg/day MeHg, (3) 500 μg/kg/day MeHg, and (4) vehicle, and treated on the test day with MK-801 (0.15 mg/kg i.p.), an antagonist of the N-methyl D-aspartate receptor.
The effects were evaluated in male offspring through the open field test, object recognition test, Morris water maze, and conditioned taste aversion.
For each test and stage assessed, different groups of animals were used.
MeHg exposure, in a dose-dependent manner, disrupted exploratory behaviour, recognition memory, spatial learning, and acquisition of aversive memories in periadolescent rats, but alterations were not observed in littermates tested in young adulthood.
These results suggest that developmental low-dose exposure to MeHg induces age-dependent detrimental effects.
The relevance of decreasing exposure to MeHg in humans remains to be determined.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Albores-García, Damaris& Acosta-Saavedra, Leonor C.& Hernandez, Alberto J.& Loera, Miriam J.& Calderón-Aranda, Emma S.. 2016. Early Developmental Low-Dose Methylmercury Exposure Alters Learning and Memory in Periadolescent but Not Young Adult Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098510
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Albores-García, Damaris…[et al.]. Early Developmental Low-Dose Methylmercury Exposure Alters Learning and Memory in Periadolescent but Not Young Adult Rats. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098510
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Albores-García, Damaris& Acosta-Saavedra, Leonor C.& Hernandez, Alberto J.& Loera, Miriam J.& Calderón-Aranda, Emma S.. Early Developmental Low-Dose Methylmercury Exposure Alters Learning and Memory in Periadolescent but Not Young Adult Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098510
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098510
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر