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Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats
المؤلفون المشاركون
Li, Ya-li
Zhang, Li
Tang, Wen-jing
Ma, Deng-lei
Li, Lin
Zhang, Lan
Yang, Cui-cui
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Purpose.
This study was to investigate the effects of cornel iridoid glycoside (CIG) on spinal cord injury (SCI) in rats.
Methods.
The thoracic cord (at T9) of rats was injured by clip compression for 30 sec.
Locomotor function was assessed using the Basso, Beattie, and Bresnahan (BBB) rating scale.
Neuroanatomic stereological parameters as well as Nogo-A, p75 neurotrophin receptor (p75NTR), and ROCKII expression were measured by histological processing, immunohistochemistry, and stereological analyses.
The axons passing through the lesion site were detected by BDA tracing.
Results.
Intragastric administration of CIG (60 and 180 mg/kg) improved the locomotor impairment at 10, 17, 24, and 31 days post-injury (dpi) compared with untreated SCI model rats.
CIG treatment decreased the volume of the lesion epicenter (LEp) and increased the volume of spared tissue and the number of surviving neurons in the injured spinal cord at 31 dpi.
CIG promoted the growth of BDA-positive axons and their passage through the lesion site and decreased the expression of Nogo-A, p75NTR, and ROCKII both in and around the LEp.
Conclusion.
CIG improved the locomotor impairment, decreased tissue damage, and downregulated the myelin-associated inhibition signaling pathway in SCI rats.
The results suggest that CIG may be beneficial for SCI therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Wen-jing& Ma, Deng-lei& Yang, Cui-cui& Zhang, Li& Li, Ya-li& Zhang, Lan…[et al.]. 2016. Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats. BioMed Research International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098532
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Wen-jing…[et al.]. Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats. BioMed Research International No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1098532
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Wen-jing& Ma, Deng-lei& Yang, Cui-cui& Zhang, Li& Li, Ya-li& Zhang, Lan…[et al.]. Cornel Iridoid Glycoside Improves Locomotor Impairment and Decreases Spinal Cord Damage in Rats. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1098532
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098532
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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