Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts
المؤلفون المشاركون
Yamanaka, Hisashi
Nanke, Yuki
Yago, Toru
Kawamoto, Manabu
Kobashigawa, Tsuyoshi
Kotake, Shigeru
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-14
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Objectives.
Drug repositioning or drug reprofiling (DR) has recently been growing in importance.
DR has a significant advantage over traditional drug development because the repositioned drug has already passed toxicity tests; its safety is known, and the risk of adverse toxicology is reduced.
In the current study, we investigated the role of rebamipide, a mucosa-protecting agent, with recently reported anti-inflammatory function, in human osteoclastogenesis.
Methods.
Peripheral blood mononuclear cells (PBMCs) were cultured in the presence of M-CSF and sRANKL.
Osteoclast formation was evaluated by immunohistological staining for CD51/61 (vitronectin receptors).
Osteoclast formation, in the presence or absence of rebamipide (0, 1, and 3 mM), was observed by time-lapse photography and actin ring formation.
The number of absorption sites and area of absorption were calculated using Osteologic™ plates.
Pit formation was studied by 3D-SEM.
Results.
Rebamipide inhibited human osteoclast formation at 3 mM, a pharmacological concentration, and inhibited resorbing activity dose-dependently.
Rebamipide induced the degradation of actin rings in mature osteoclasts.
This mechanism may involve inhibiting the osteoclast fusion pathway through reducing the expression of DC-specific transmembrane protein (DC-STAMP).
Conclusions.
The present study suggests that rebamipide would be useful as a novel agent for osteoporosis and rheumatoid arthritis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nanke, Yuki& Kobashigawa, Tsuyoshi& Yago, Toru& Kawamoto, Manabu& Yamanaka, Hisashi& Kotake, Shigeru. 2016. Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098599
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nanke, Yuki…[et al.]. Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098599
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nanke, Yuki& Kobashigawa, Tsuyoshi& Yago, Toru& Kawamoto, Manabu& Yamanaka, Hisashi& Kotake, Shigeru. Rebamipide, an Amino Acid Analog of 2(1H)-Quinolinone, Inhibits the Formation of Human Osteoclasts. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098599
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098599
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر