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Efficacy and Safety of Novel Agent-Based Therapies for Multiple Myeloma: A Meta-Analysis
المؤلفون المشاركون
Wang, Xiaoxue
Li, Yan
Yan, Xiaojing
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-01
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
This study aimed at comparing bortezomib, thalidomide, and lenalidomide in patients with multiple myeloma (MM) for safety and efficacy using meta-analysis.
This meta-analysis identified 17 randomized controlled trials (RCTs) including 6742 patients.
These RCTs were separated according to the different agent-based regimens and to autologous stem-cell transplantation (ASCT).
Complete response (CR), progression-free survival (PFS), overall survival (OS), and adverse events (AE) were combined.
The total weighted risk ratio (RR) of CR was 3.29 [95% confidence interval (95% CI): 2.22–4.88] (P<0.0001) for the novel agent-based regimens.
These novel agent-based regimens showed greater benefit in terms of PFS of all subgroups irrespective of whether the patient received ASCT or not.
The hazard ratio (HR) for PFS was 0.64 [95% CI: 0.60–0.69] (P<0.00001).
Improvements of OS could be found only in the bortezomib- and thalidomide-based regimens without ASCT.
The pooled HRs were 0.74 [95% CI: 0.65–0.86] (P<0.0001) and 0.80 [95% CI: 0.70–0.90] (P=0.0004), respectively.
Several AEs were shown more frequently in the novel agent-based regimens compared with controls such as hematologic events (neutropenia, anemia, and thrombocytopenia), gastrointestinal infection, peripheral neuropathy, thrombosis, and embolism events.
In conclusion, in spite of the AEs, novel agent-based regimens are safe and effective for the treatment of MM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Xiaoxue& Li, Yan& Yan, Xiaojing. 2016. Efficacy and Safety of Novel Agent-Based Therapies for Multiple Myeloma: A Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1098611
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Xiaoxue…[et al.]. Efficacy and Safety of Novel Agent-Based Therapies for Multiple Myeloma: A Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1098611
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Xiaoxue& Li, Yan& Yan, Xiaojing. Efficacy and Safety of Novel Agent-Based Therapies for Multiple Myeloma: A Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1098611
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098611
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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