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Effect of Anti-TNF Antibodies on Clinical Response in Rheumatoid Arthritis Patients: A Meta-Analysis
المؤلفون المشاركون
Wu, Chunxiao
Wang, Shengxu
Xian, Peifeng
Yang, Lu
Chen, Ying
Mo, Xianjie
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Antitumor necrosis factor (anti-TNF) drugs have been applied for rheumatoid arthritis (RA) treatment; however, patients having anti-drug antibodies (ADAbs) do not benefit from these drugs.
The meta-analysis aims to comprehensively assess the relationship between ADAb positive (ADAb+) and anti-TNF response in RA patients.
Methods.
Observational studies comparing different clinical response between ADAb+ and ADAb negative groups were included.
Odds ratio (OR) with its corresponding 95% confidence interval (CI) was used as effect size.
Subgroup analyses stratified by TNF inhibitor types and assay methods for ADAb detection were performed.
Results.
Totally, 10 eligible studies containing 1806 subjects were included.
ADAb+ was significantly associated with reduced anti-TNF response to RA at all the time points after follow-up ( P < 0.001 ).
Subgroup analysis also supported this significant association ( P < 0.05 ), except for enzyme-linked immunosorbent assay (ELISA) group at 3 months, infliximab (INF) and enzyme-linked immunosorbent assay (ELISA) groups at 6 months, and Immunological Multi-Parameter Chip Technology (IMPACT) group at 12 months.
Conclusion.
ADAb+ was significantly associated with reduced clinical response in RA patients, and other alternatives should be considered in RA patients presenting ADAb+.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wu, Chunxiao& Wang, Shengxu& Xian, Peifeng& Yang, Lu& Chen, Ying& Mo, Xianjie. 2016. Effect of Anti-TNF Antibodies on Clinical Response in Rheumatoid Arthritis Patients: A Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098738
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wu, Chunxiao…[et al.]. Effect of Anti-TNF Antibodies on Clinical Response in Rheumatoid Arthritis Patients: A Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098738
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wu, Chunxiao& Wang, Shengxu& Xian, Peifeng& Yang, Lu& Chen, Ying& Mo, Xianjie. Effect of Anti-TNF Antibodies on Clinical Response in Rheumatoid Arthritis Patients: A Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098738
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098738
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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