Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers

المؤلفون المشاركون

Fernandez-Mejia, C.
Riverón-Negrete, Leticia
Sicilia-Argumedo, Gloria
Álvarez-Delgado, Carolina
Alcántar-Fernández, Jonathan
Coballase-Urrutia, Elvia

المصدر

BioMed Research International

العدد

المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2016-12-25

دولة النشر

مصر

عدد الصفحات

9

التخصصات الرئيسية

الطب البشري

الملخص EN

Pharmacological concentrations of biotin have pleiotropic effects.

Several reports have documented that biotin supplementation decreases hyperglycemia.

We have shown that a biotin-supplemented diet increased insulin secretion and the mRNA abundance of proteins regulating insulin transcription and secretion.

We also found enlarged pancreatic islets and modified islet morphology.

Other studies have shown that pharmacological concentrations of biotin modify tissue structure.

Although biotin administration is considered safe, little attention has been given to its effect on tissue structure.

In this study, we investigated the effect of biotin supplementation on hepatic morphology and liver toxicity markers.

Male BALB/cAnN Hsd mice were fed a control or a biotin-supplemented diet for 8 weeks.

Versus the control mice, biotin-supplemented mice had an altered portal triad with dilated sinusoids, increased vascularity, and bile conducts.

Furthermore, we observed an increased proportion of nucleomegaly and binucleated hepatocytes.

In spite of the liver morphological changes, no differences were observed in the serum liver damage indicators, oxidative stress markers, or antioxidant enzymes.

Our data demonstrate for the first time that biotin supplementation affects liver morphology in normal mice, and that these modifications are not paralleled with damage markers.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Riverón-Negrete, Leticia& Sicilia-Argumedo, Gloria& Álvarez-Delgado, Carolina& Coballase-Urrutia, Elvia& Alcántar-Fernández, Jonathan& Fernandez-Mejia, C.. 2016. Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098759

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Riverón-Negrete, Leticia…[et al.]. Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1098759

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Riverón-Negrete, Leticia& Sicilia-Argumedo, Gloria& Álvarez-Delgado, Carolina& Coballase-Urrutia, Elvia& Alcántar-Fernández, Jonathan& Fernandez-Mejia, C.. Dietary Biotin Supplementation Modifies Hepatic Morphology without Changes in Liver Toxicity Markers. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1098759

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1098759