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Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder
المؤلفون المشاركون
Wyckoff, Gerald J.
Sabbagh, Ubadah
Mullegama, Saman
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The purpose of this study was to find genes linked with eating disorders and associated with both metabolic and neural systems.
Our operating hypothesis was that there are genetic factors underlying some eating disorders resting in both those pathways.
Specifically, we are interested in disorders that may rest in both sleep and metabolic function, generally called Night Eating Syndrome (NES).
A meta-analysis of the Gene Expression Omnibus targeting the mammalian nervous system, sleep, and obesity studies was performed, yielding numerous genes of interest.
Through a text-based analysis of the results, a number of potential candidate genes were identified.
VGF, in particular, appeared to be relevant both to obesity and, broadly, to brain or neural development.
VGF is a highly connected protein that interacts with numerous targets via proteolytically digested peptides.
We examined VGF from an evolutionary perspective to determine whether other available evidence supported a role for the gene in human disease.
We conclude that some of the already identified variants in VGF from human polymorphism studies may contribute to eating disorders and obesity.
Our data suggest that there is enough evidence to warrant eGWAS and GWAS analysis of these genes in NES patients in a case-control study.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sabbagh, Ubadah& Mullegama, Saman& Wyckoff, Gerald J.. 2016. Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098761
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sabbagh, Ubadah…[et al.]. Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1098761
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sabbagh, Ubadah& Mullegama, Saman& Wyckoff, Gerald J.. Identification and Evolutionary Analysis of Potential Candidate Genes in a Human Eating Disorder. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1098761
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098761
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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