Immunosuppressive Treatment for Lupus Nephritis: Long-Term Results in 178 Patients
المؤلفون المشاركون
Zakharova, Elena V.
Makarova, Tatiana A.
Zvonova, Elena V.
Anilina, Alina M.
Stolyarevich, Ekaterina S.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-05
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Lupus nephritis is one of the most severe Systemic Lupus Erythematosus features, defining treatment modality and prognosis.
Our retrospective study, including 178 patients treated for lupus nephritis during 23 years with mostly cyclophosphamide-based initial regimens followed by azathioprine or mycophenolic acid, demonstrates 84.8% of renal response with 19.2% of flares, 15-year patient survival 78.7% and kidney survival 76.3%, and low damage accrual.
Both patient and kidney survival significantly differ for subgroups that achieved complete or partial renal response and nonresponders: patient 15-year survival 95% versus 65% versus 35%; kidney 15-year survival 100% versus 58% versus 0%, respectively.
51% (24 out of 47) of patients evaluated at the end of the study period sustained complete renal response; however, only 9 of them had 0 disease activity according to SELENA SLEDAI scale, while 13 patients had scores 2–4 due to the serological abnormalities only.
We conclude that (1) initial treatment with cyclophosphamide followed by azathioprine is effective and can be used in agreement with International Guidelines until the evidence for biological treatments benefits becomes available; (2) complete and even partial renal response have positive prognostic value, and failure to achieve renal response negatively influences kidney and patient survival; (3) the validity of complete renal response in SLE is questioned by the absence of conventional definition of SLE remission.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zakharova, Elena V.& Makarova, Tatiana A.& Zvonova, Elena V.& Anilina, Alina M.& Stolyarevich, Ekaterina S.. 2016. Immunosuppressive Treatment for Lupus Nephritis: Long-Term Results in 178 Patients. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zakharova, Elena V.…[et al.]. Immunosuppressive Treatment for Lupus Nephritis: Long-Term Results in 178 Patients. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zakharova, Elena V.& Makarova, Tatiana A.& Zvonova, Elena V.& Anilina, Alina M.& Stolyarevich, Ekaterina S.. Immunosuppressive Treatment for Lupus Nephritis: Long-Term Results in 178 Patients. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر