Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis
المؤلفون المشاركون
Jung, Hee Jae
Kim, Kwan-Il
Kim, Su Kang
Chung, Joo-Ho
Kang, Sang Wook
Ban, Ju Yeon
Kim, Jinju
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-18
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The relationship between polymorphism of the angiotensin I converting enzyme (ACE) gene and chronic obstructive pulmonary disease (COPD) has been examined in many previous studies.
However, their results were controversial.
Therefore, we performed a meta-analysis to evaluate the relationship between the ACE gene and the risk of COPD.
Fourteen case-control studies were included in this meta-analysis.
The pooled p value, odds ratio (OR), and 95% confidence interval (95% CI) were used to investigate the strength of the association.
The meta-analysis was performed using comprehensive meta-analysis software.
Our meta-analysis results revealed that ACE polymorphisms were not related to the risk of COPD ( p > 0.05 in each model).
In further analyses based on ethnicity, we observed an association between insertion/deletion polymorphism of the ACE gene and risk of COPD in the Asian population (codominant 2, OR = 3.126, 95% CI = 1.919–5.093, p < 0.001 ; recessive, OR = 3.326, 95% CI = 2.190–5.050, p < 0.001 ) but not in the Caucasian population ( p > 0.05 in each model).
In conclusion, the present meta-analysis indicated that the insertion/deletion polymorphism of the ACE gene may be associated with susceptibility to COPD in the Asian population but not in the Caucasian population.
However, the results of the present meta-analysis need to be confirmed in a larger sample.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kang, Sang Wook& Kim, Su Kang& Chung, Joo-Ho& Jung, Hee Jae& Kim, Kwan-Il& Kim, Jinju…[et al.]. 2016. Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098838
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kang, Sang Wook…[et al.]. Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098838
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kang, Sang Wook& Kim, Su Kang& Chung, Joo-Ho& Jung, Hee Jae& Kim, Kwan-Il& Kim, Jinju…[et al.]. Genetic Polymorphism of Angiotensin-Converting Enzyme and Chronic Obstructive Pulmonary Disease Risk: An Updated Meta-Analysis. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098838
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098838
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر