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A Nested Case-Control Study of Association between Metabolome and Hypertension Risk
المؤلفون المشاركون
Hao, Yongchen
Wang, Ying
Xi, Lu
Li, Guoqi
Zhao, Fan
Qi, Yue
Liu, Jing
Zhao, Dong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-29
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
We aimed to explore novel small metabolites that associated with hypertension risk in a population-based nested case-control study.
Among 460 individuals with optimal blood pressure (<120/80 mmHg) at baseline, 55 progressed to hypertension during 5 years of follow-up.
Twenty-nine cases of incident hypertension and 29 controls, matched for age, sex, and baseline systolic blood pressure, were included in this study.
Serum metabolites were measured by gas chromatography-tandem mass spectrometry.
t-test and logistic regression analysis were applied to investigate the association between metabolites and incident hypertension.
Among the 241 metabolites identified in this study, baseline levels of 26 metabolites were significantly different between hypertension and control groups.
After adjusting for body mass index, smoking, and drinking, 16 out of the 26 metabolites were still associated with hypertension risk including four amino acids.
Amino acids were negatively associated with risk of future hypertension, with odds ratio (OR) ranging from 0.33 to 0.53.
Two of these amino acids were essential amino acids including threonine and phenylalanine.
Higher level of lyxose, a fermentation product of gut microbes, was associated with higher risk of hypertension.
Our study identified multiple metabolites that associated with hypertension risk.
These findings implied that low amino acid levels and gut microbiome might play an important role in the pathogenesis of hypertension.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hao, Yongchen& Wang, Ying& Xi, Lu& Li, Guoqi& Zhao, Fan& Qi, Yue…[et al.]. 2016. A Nested Case-Control Study of Association between Metabolome and Hypertension Risk. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098843
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hao, Yongchen…[et al.]. A Nested Case-Control Study of Association between Metabolome and Hypertension Risk. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098843
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hao, Yongchen& Wang, Ying& Xi, Lu& Li, Guoqi& Zhao, Fan& Qi, Yue…[et al.]. A Nested Case-Control Study of Association between Metabolome and Hypertension Risk. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098843
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098843
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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