A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage
المؤلفون المشاركون
Dervisoglu, Sergulen
Senem, Demiroz Ahu
Komur, Baran
Gokay, Banu Vural
Gokay, Nevzat Selim
Yilmaz, Ibrahim
Gokce, Alper
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-13
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The objective of this study was to investigate the effects of selective inducible nitric oxide synthase and neuronal nitric oxide synthase inhibitors on cartilage regeneration.
The study involved 27 Wistar rats that were divided into five groups.
On Day 1, both knees of 3 rats were resected and placed in a formalin solution as a control group.
The remaining 24 rats were separated into 4 groups, and their right knees were surgically damaged.
Depending on the groups, the rats were injected with intra-articular normal saline solution, neuronal nitric oxide synthase inhibitor 7-nitroindazole (50 mg/kg), inducible nitric oxide synthase inhibitor amino-guanidine (30 mg/kg), or nitric oxide precursor L-arginine (200 mg/kg).
After 21 days, the right and left knees of the rats were resected and placed in formalin solution.
The samples were histopathologically examined by a blinded evaluator and scored on 8 parameters.
Although selective neuronal nitric oxide synthase inhibition exhibited significant ( P = 0.044 ) positive effects on cartilage regeneration following cartilage damage, it was determined that inducible nitric oxide synthase inhibition had no statistically significant effect on cartilage regeneration.
It was observed that the nitric oxide synthase activation triggered advanced arthrosis symptoms, such as osteophyte formation.
The fact that selective neuronal nitric oxide synthase inhibitors were observed to have mitigating effects on the severity of the damage may, in the future, influence the development of new agents to be used in the treatment of cartilage disorders.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gokay, Nevzat Selim& Yilmaz, Ibrahim& Komur, Baran& Senem, Demiroz Ahu & Gokce, Alper& Dervisoglu, Sergulen…[et al.]. 2016. A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gokay, Nevzat Selim…[et al.]. A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gokay, Nevzat Selim& Yilmaz, Ibrahim& Komur, Baran& Senem, Demiroz Ahu & Gokce, Alper& Dervisoglu, Sergulen…[et al.]. A Comparison of the Effects of Neuronal Nitric Oxide Synthase and Inducible Nitric Oxide Synthase Inhibition on Cartilage Damage. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر