Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor
المؤلفون المشاركون
Marchlewska, Katarzyna
Filipiak, Eliza
Walczak-Jedrzejowska, Renata
Oszukowska, Elzbieta
Sobkiewicz, Slawomir
Wojt, Malgorzata
Chmiel, Jacek
Kula, Krzysztof
Slowikowska-Hilczer, Jolanta
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-24
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Objective.
To investigate sperm DNA fragmentation and sperm functional maturity in men from infertile couples (IC) and men with testicular germ cell tumor (TGCT).
Materials and Methods.
Semen samples were collected from 312 IC men and 23 men with TGCT before unilateral orchiectomy and oncological treatment.
The sperm chromatin dispersion test was performed to determine DNA fragmentation index (DFI) and the ability of sperm to bind with hyaluronan (HA) was assessed.
Results.
In comparison with the IC men, the men with TGCT had a higher percentage of sperm with fragmented DNA (median 28% versus 21%; p < 0.01 ) and a lower percentage of HA-bound sperm (24% versus 66%; p < 0.001 ).
Normal results of both analyses were observed in 24% of IC men and 4% of men with TGCT.
Negative Spearman’s correlations were found between DFI and the percentage of HA-bound sperm in the whole group and in IC subjects and those with TGCT analyzed separately.
Conclusions.
Approximately 76% of IC men and 96% with TGCT awaiting orchiectomy demonstrated DNA fragmentation and/or sperm immaturity.
We therefore recommend sperm banking after unilateral orchiectomy, but before irradiation and chemotherapy; the use of such a deposit appears to be a better strategy to obtain functionally efficient sperms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Marchlewska, Katarzyna& Filipiak, Eliza& Walczak-Jedrzejowska, Renata& Oszukowska, Elzbieta& Sobkiewicz, Slawomir& Wojt, Malgorzata…[et al.]. 2016. Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098878
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Marchlewska, Katarzyna…[et al.]. Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1098878
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Marchlewska, Katarzyna& Filipiak, Eliza& Walczak-Jedrzejowska, Renata& Oszukowska, Elzbieta& Sobkiewicz, Slawomir& Wojt, Malgorzata…[et al.]. Sperm DNA Fragmentation Index and Hyaluronan Binding Ability in Men from Infertile Couples and Men with Testicular Germ Cell Tumor. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1098878
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098878
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر