Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?
المؤلفون المشاركون
Thakkinstian, Ammarin
Pongpit, Jamrus
Porntharukchareon, Saneerat
Kaewduang, Piyaporn
Promson, Kwannapa
Stitchantrakul, Wasana
Petraksa, Supanna
Kositchaiwat, Chomsri
Rajatanavin, Natta
Sobhonslidsuk, Abhasnee
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
An increased prevalence of metabolic syndrome including nonalcoholic fatty liver disease (NAFLD) was reported in psoriasis.
NAFLD can progress to nonalcoholic steatohepatitis and fibrosis.
Transient elastography (TE) is a noninvasive liver fibrosis assessment.
We evaluated the prevalence of significant liver fibrosis or high liver stiffness measurement (LSM) using the LSM cutoff over 7 kPa and its associated factors in psoriatic patients.
Methods.
Subjects underwent TE and ultrasonography.
Univariate and multivariate analysis were performed for the associated factors.
Results.
One hundred and sixty-eight patients were recruited.
Three patients were excluded due to TE failure.
Mean BMI was 24.8 ± 4.7 kg/m2.
NAFLD, metabolic syndrome, and diabetes were seen in 105 (63.6%), 83 (50.3%), and 31 (18.8%) patients.
The total cumulative dose of methotrexate over 1.5 g was seen in 39 (23.6%) patients.
Mean LSM was 5.3 ± 2.9 kPa.
High LSM was found in 18 (11.0%) patients.
Waist circumference (OR: 1.24; 95% CI: 1.11–1.38; P = 0.0002 ), diabetes (OR: 12.70; 95% CI: 1.84–87.70; P = 0.010 ), and AST (OR: 1.08; 95% CI: 1.02–1.16; P = 0.017 ) were associated with high LSM.
Conclusion.
11% of psoriatic patients had significant liver fibrosis by high LSM.
Waist circumference, diabetes, and AST level were the independent predictors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pongpit, Jamrus& Porntharukchareon, Saneerat& Kaewduang, Piyaporn& Promson, Kwannapa& Stitchantrakul, Wasana& Petraksa, Supanna…[et al.]. 2016. Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098895
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pongpit, Jamrus…[et al.]. Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098895
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pongpit, Jamrus& Porntharukchareon, Saneerat& Kaewduang, Piyaporn& Promson, Kwannapa& Stitchantrakul, Wasana& Petraksa, Supanna…[et al.]. Liver Stiffness Measurement in Psoriasis: Do Metabolic or Disease Factors Play the Important Role?. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098895
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098895
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر