Immunopathological Features of Canine Myocarditis Associated with Leishmania infantum Infection
المؤلفون المشاركون
Russo, Valeria
Paciello, Orlando
Iovane, Valentina
Papparella, Serenella
Rinaldi, Laura
Domagala, Iwona O.
Costagliola, Alessandro
Piegari, Giuseppe
Ciccarelli, Davide
Oliva, Gaetano
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-19
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Myocarditis associated with infectious diseases may occur in dogs, including those caused by the protozoa Neospora caninum, Trypanosoma cruzi, Babesia canis, and Hepatozoon canis.
However, although cardiac disease due to Leishmania infection has also been documented, the immunopathological features of myocarditis have not been reported so far.
The aim of this study was to examine the types of cellular infiltrates and expression of MHC classes I and II in myocardial samples obtained at necropsy from 15 dogs with an established intravitam diagnosis of visceral leishmaniasis.
Pathological features of myocardium were characterized by hyaline degeneration of cardiomyocytes, necrosis, and infiltration of mononuclear inflammatory cells consisting of lymphocytes and macrophages, sometimes with perivascular pattern; fibrosis was also present in various degrees.
Immunophenotyping of inflammatory cells was performed by immunohistochemistry on cryostat sections obtained from the heart of the infected dogs.
The predominant leukocyte population was CD8+ with a fewer number of CD4+ cells.
Many cardiomyocytes expressed MHC classes I and II on the sarcolemma.
Leishmania amastigote forms were not detected within macrophages or any other cell of the examined samples.
Our study provided evidence that myocarditis in canine visceral leishmaniasis might be related to immunological alterations associated with Leishmania infection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Costagliola, Alessandro& Piegari, Giuseppe& Domagala, Iwona O.& Ciccarelli, Davide& Iovane, Valentina& Oliva, Gaetano…[et al.]. 2016. Immunopathological Features of Canine Myocarditis Associated with Leishmania infantum Infection. BioMed Research International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098910
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Costagliola, Alessandro…[et al.]. Immunopathological Features of Canine Myocarditis Associated with Leishmania infantum Infection. BioMed Research International No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1098910
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Costagliola, Alessandro& Piegari, Giuseppe& Domagala, Iwona O.& Ciccarelli, Davide& Iovane, Valentina& Oliva, Gaetano…[et al.]. Immunopathological Features of Canine Myocarditis Associated with Leishmania infantum Infection. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1098910
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098910
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر