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Silver-Containing Hydroxyapatite Coating Reduces Biofilm Formation by Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo
المؤلفون المشاركون
Sonohata, Motoki
Miyamoto, Hiroshi
Ueno, Masaya
Shobuike, Takeo
Kobatake, Tomoki
Tsukamoto, Masatsugu
Eto, Shuichi
Noda, Iwao
Mawatari, Masaaki
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Biofilm-producing bacteria are the principal causes of infections associated with orthopaedic implants.
We previously reported that silver-containing hydroxyapatite (Ag-HA) coatings exhibit high antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
In the present study, we evaluated the effects of Ag-HA coating of implant surfaces on biofilm formation.
Titanium disks (14-mm diameter, 1-mm thickness), one surface of which was coated with HA or 0.5%–3.0% Ag-HA with a thermal spraying technique, were used.
In vitro, the disks were inoculated with an MRSA suspension containing 4×105 CFU and incubated for 1-2 weeks.
In vivo, MRSA-inoculated HA and 3% Ag-HA disks (8.8–10.0 × 108 CFU) were implanted subcutaneously on the back of rats for 1–7 days.
All disks were subsequently stained with a biofilm dye and observed under a fluorescence microscope, and biofilm coverage rates (BCRs) were calculated.
The BCRs on the Ag-HA coating were significantly lower than those on the HA coating at all time points in vitro (p<0.05).
Similar results were observed in vivo (p<0.001) without argyria.
Ag-HA coating reduced biofilm formation by MRSA in vitro and in vivo; therefore, Ag-HA coating might be effective for reducing implant-associated infections.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ueno, Masaya& Miyamoto, Hiroshi& Tsukamoto, Masatsugu& Eto, Shuichi& Noda, Iwao& Shobuike, Takeo…[et al.]. 2016. Silver-Containing Hydroxyapatite Coating Reduces Biofilm Formation by Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo. BioMed Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098956
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ueno, Masaya…[et al.]. Silver-Containing Hydroxyapatite Coating Reduces Biofilm Formation by Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo. BioMed Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1098956
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ueno, Masaya& Miyamoto, Hiroshi& Tsukamoto, Masatsugu& Eto, Shuichi& Noda, Iwao& Shobuike, Takeo…[et al.]. Silver-Containing Hydroxyapatite Coating Reduces Biofilm Formation by Methicillin-Resistant Staphylococcus aureus In Vitro and In Vivo. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1098956
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1098956
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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