Deposition of BACE-1 Protein in the Brains of APPPS1 Double Transgenic Mice
المؤلفون المشاركون
Wang, Jun-Hui
Luo, Gang
Xu, Hongxia
Huang, Yinuo
Mo, Dapeng
Song, Ligang
Jia, Baixue
Jin, Zhanqiang
Miao, Zhongrong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-18
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The main causes of Alzheimer’s disease remain elusive.
Previous data have implicated the BACE-1 protein as a central player in the pathogenesis of Alzheimer’s disease.
However, many inhibitors of BACE-1 have failed during preclinical and clinical trials for AD treatment.
Therefore, uncovering the exact role of BACE-1 in AD may have significant impact on the future development of therapeutic agents.
Three- and six-month-old female APP/PS1 double transgenic mice were used to study abnormal accumulation of BACE-1 protein in brains of mice here.
Immunofluorescence, immunohistochemistry, and western blot were performed to measure the distributing pattern and expression level of BACE-1.
We found obvious BACE-1 protein accumulation in 3-month-old APP/PS1 mice, which had increased by the time of 6 months.
Coimmunostaining results showed BACE-1 surrounded amyloid plaques in brain sections.
The abnormal protein expression might not be attributable to the upregulation of BACE-1 protein, as no significant difference of protein expression was observed between wild-type and APP/PS1 mice.
With antibodies against BACE-1 and CD31, we found a high immunoreactive density of BACE-1 protein on the outer layer of brain blood vessels.
The aberrant distribution of BACE-1 in APP/PS1 mice suggests BACE-1 may be involved in the microvascular abnormality of AD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luo, Gang& Xu, Hongxia& Huang, Yinuo& Mo, Dapeng& Song, Ligang& Jia, Baixue…[et al.]. 2016. Deposition of BACE-1 Protein in the Brains of APPPS1 Double Transgenic Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099042
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luo, Gang…[et al.]. Deposition of BACE-1 Protein in the Brains of APPPS1 Double Transgenic Mice. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099042
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luo, Gang& Xu, Hongxia& Huang, Yinuo& Mo, Dapeng& Song, Ligang& Jia, Baixue…[et al.]. Deposition of BACE-1 Protein in the Brains of APPPS1 Double Transgenic Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099042
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099042
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر