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Early Inflammatory Response following Traumatic Brain Injury in Rabbits Using USPIO- and Gd-Enhanced MRI
المؤلفون المشاركون
Ouyang, Lin
Zeng, Si
Lu, Guang Ming
Zheng, Gang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-27
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Purpose.
To monitor the inflammatory response (IR) following traumatic brain injury (TBI) before and after the rehabilitation of the blood-brain barrier (BBB) in rabbits using USPIO- and Gd-enhanced MRI.
Materials and Methods.
Twenty white big-eared rabbits with mild TBI (mTBI) were randomly and equally divided into four groups.
Rabbits were sacrificed for the brain specimens immediately after the last MRI-monitoring.
Sequences were tse-T1WI, tse-T2WI, Gd-T1WI, and USPIO-T1WI.
Dynamical MRI presentations were evaluated and compared with pathological findings for each group.
Results.
Twenty-four hours after injury, all rabbits displayed high signal foci on T2WI, while only 55% lesions could be found on Gd-T1WI and none on USPIO-T1WI.
The lesions were enhanced on Gd-T1WI in 100% subjects after 48 h and the enhancement sizes augmented to the largest after 72 h.
At the time point of 72 h after TBI, 90% lesions were enhanced by USPIO.
Five days after injury, 19 lesions showed decreased Gd-enhancement and one disappeared; however, USPIO-enhancement became larger than before.
Pathological findings showed microglias slightly appeared in dense leukocytes at 48 h, but became the dominant inflammatory cells after five days.
Conclusions.
Dynamic IR following injury could be monitored by combination of Gd- and USPIO-MRI in mTBI rabbits.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ouyang, Lin& Zeng, Si& Zheng, Gang& Lu, Guang Ming. 2016. Early Inflammatory Response following Traumatic Brain Injury in Rabbits Using USPIO- and Gd-Enhanced MRI. BioMed Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099057
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ouyang, Lin…[et al.]. Early Inflammatory Response following Traumatic Brain Injury in Rabbits Using USPIO- and Gd-Enhanced MRI. BioMed Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099057
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ouyang, Lin& Zeng, Si& Zheng, Gang& Lu, Guang Ming. Early Inflammatory Response following Traumatic Brain Injury in Rabbits Using USPIO- and Gd-Enhanced MRI. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099057
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099057
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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