Identification of Potential Key lncRNAs and Genes Associated with Aging Based on Microarray Data of Adipocytes from Mice
المؤلفون المشاركون
Yang, Yi
Teng, Zongyan
Meng, Songyan
Yu, Weigang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objective.
This study aimed to screen potential crucial lncRNAs and genes involved in aging.
Methods.
The data of 9 peripheral white adipocytes, respectively, taken from male C57BL/6J mice (6 months, 14 months, and 18 months of age) in GSE25905 were used in this study.
Differentially time series expressed lncRNA genes (DE-lncRNAs) and mRNA genes (DEGs) were identified.
After cluster analysis of lncRNAs expression pattern, target genes of DE-lncRNAs were predicted from the DEGs, and functional analysis for target genes was conducted.
Results.
A total of 8301 time series-related DEGs and 43 time series-related DE-lncRNAs were identified.
Among them, 41 DE-lncRNAs targeted 1880 DEGs.
The DEGs positively regulated by DE-lncRNAs were mainly related to the development of blood vessel and the pathways of cholesterol biosynthesis and elastic fibre formation.
Furthermore, the DEGs negatively regulated by DE-lncRNAs were correlated with protein metabolism.
Conclusion.
These DE-lncRNAs and DEGs are potentially involved in the process of aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Yi& Teng, Zongyan& Meng, Songyan& Yu, Weigang. 2016. Identification of Potential Key lncRNAs and Genes Associated with Aging Based on Microarray Data of Adipocytes from Mice. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099250
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Yi…[et al.]. Identification of Potential Key lncRNAs and Genes Associated with Aging Based on Microarray Data of Adipocytes from Mice. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1099250
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Yi& Teng, Zongyan& Meng, Songyan& Yu, Weigang. Identification of Potential Key lncRNAs and Genes Associated with Aging Based on Microarray Data of Adipocytes from Mice. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099250
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099250
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر