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Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity
المؤلفون المشاركون
Ceausu, Raluca A.
Raica, Marius
Rusu, Laura Cristina
Gaje, Pusa Nela
Jitariu, Adriana
Popovici, Ramona Amina
Stratul, Stefan-Ioan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-26
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Although mast cells (MCs) have been discovered over 130 years ago, their function was almost exclusively linked to allergic affections.
At the time being, it is well known that MCs possess a great variety of roles, in both physiologic and pathologic conditions.
In the oral tissues, MCs release different proinflammatory cytokines, tumor necrosis factor alpha (TNF-α), that promote leukocyte infiltration in various inflammatory states of the oral cavity.
These cells play a key role in the inflammatory process and, as a consequence, their number changes in different pathologic conditions of the oral cavity, like gingivitis, periodontitis, and so on.
MCs also represent a rich source of proteases, especially of mast cell tryptase and chymase, which directly degrade the extracellular matrix through their proteolytic activity and thus indirectly stimulate angiogenesis and facilitate invasion and metastasis.
It may be stated that mast cells could have an impact on primary tumor development, progression, and metastases in oral squamous cell carcinoma.
By understanding the role of mast cells in the pathogenesis of different inflammatory and tumor diseases of the oral cavity, these cells may become therapeutic targets that could possibly improve the prognosis and survival of these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gaje, Pusa Nela& Ceausu, Raluca A.& Jitariu, Adriana& Stratul, Stefan-Ioan& Rusu, Laura Cristina& Popovici, Ramona Amina…[et al.]. 2016. Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity. BioMed Research International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099258
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gaje, Pusa Nela…[et al.]. Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity. BioMed Research International No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1099258
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gaje, Pusa Nela& Ceausu, Raluca A.& Jitariu, Adriana& Stratul, Stefan-Ioan& Rusu, Laura Cristina& Popovici, Ramona Amina…[et al.]. Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1099258
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099258
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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