![](/images/graphics-bg.png)
Thrombin Maybe Plays an Important Role in MK Differentiation into Platelets
المؤلفون المشاركون
Yu, Aiping
Yang, Xiao-Lei
Ge, Meng-Kai
Mao, De-Kui
Lv, Ying-Tao
Sun, Shu-Yan
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-15
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Objectives.
After development and differentiation, megakaryocytes (MKs) can produce platelets.
As is well known, thrombopoietin (TPO) can induce MKs to differentiate.
The effect of thrombin on MKs differentiation is not clear.
In this study, we used a human megakaryoblastic leukemia cell line (Meg-01) to assess the effect of thrombin on MKs differentiation.
Methods.
In order to interrogate the role of thrombin in Meg-01 cells differentiation, the changes of morphology, cellular function, and expression of diverse factors were analyzed.
Results.
The results show that thrombin suppresses Meg-01 cells proliferation and induces apoptosis and cell cycle arrest.
Thrombin upregulates the expression of CD41b, which is one of the most important MK markers.
Globin transcription factor 1 (GATA-1), an important transcriptional regulator, controls MK development and maturation.
The expression of GATA-1 is also upregulated by thrombin in Meg-01 cells.
The expression of B-cell lymphoma 2 (Bcl-2), an apoptosis-inhibitory protein, is downregulated by thrombin.
Phosphorylated protein kinase B (p-AKT) and phosphorylated extracellular signal-regulated kinase (p-ERK) were upregulated by thrombin in Meg-01 cells.
All the results are consistent with Meg-01 cells treated with TPO.
Discussion and Conclusion.
In conclusion, all these data indicate that thrombin maybe plays an important role in MK differentiation into platelets.
However, whether the platelet-like particles are certainly platelets remains unknown.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yang, Xiao-Lei& Ge, Meng-Kai& Mao, De-Kui& Lv, Ying-Tao& Sun, Shu-Yan& Yu, Aiping. 2016. Thrombin Maybe Plays an Important Role in MK Differentiation into Platelets. BioMed Research International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099274
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yang, Xiao-Lei…[et al.]. Thrombin Maybe Plays an Important Role in MK Differentiation into Platelets. BioMed Research International No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1099274
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yang, Xiao-Lei& Ge, Meng-Kai& Mao, De-Kui& Lv, Ying-Tao& Sun, Shu-Yan& Yu, Aiping. Thrombin Maybe Plays an Important Role in MK Differentiation into Platelets. BioMed Research International. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1099274
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099274
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)