Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat
المؤلفون المشاركون
Soleimani Asl, Sara
Pourheydar, Bagher
Azimzadeh, Mostafa
Rezaei Moghadam, Adel
Marzban, Asghar
Mehdizadeh, Mehdi
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-25
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Cell therapy is the most advanced treatment of the cerebral ischemia, nowadays.
Herein, we discuss the neuroprotective effects of bone marrow mesenchymal stem cells (BMSCs) on rat hippocampal cells following intravenous injection of these cells in an ischemia-reperfusion model.
Adult male Wistar rats were divided into 5 groups: control, sham (surgery without blockage of common carotid arteries), ischemia (common carotid arteries were blocked for 30 min prior to reperfusion), vehicle (7 days after ischemia PBS was injected via the tail vein), and treatment (injections of BMSC into the tail veins 7 days after ischemia).
We performed neuromuscular and vestibulomotor function tests to assess behavioral function and, finally, brains were subjected to hematoxylin and eosin (H&E), anti-Brdu immunohistochemistry, and TUNEL staining.
The ischemia group had severe apoptosis.
The group treated with BMSCs had a lower mortality rate and also had significant improvement in functional recovery (P<0.001).
Ischemia-reperfusion for 30 min causes damage and extensive neuronal death in the hippocampus, especially in CA1 and CA3 regions, leading to several functional and neurological deficits.
In conclusion, intravenous injection of BMSCs can significantly decrease the number of apoptotic neurons and significantly improve functional recovery, which may be a beneficial treatment method for ischemic injuries.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pourheydar, Bagher& Soleimani Asl, Sara& Azimzadeh, Mostafa& Rezaei Moghadam, Adel& Marzban, Asghar& Mehdizadeh, Mehdi. 2016. Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat. Behavioural Neurology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099435
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pourheydar, Bagher…[et al.]. Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat. Behavioural Neurology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099435
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pourheydar, Bagher& Soleimani Asl, Sara& Azimzadeh, Mostafa& Rezaei Moghadam, Adel& Marzban, Asghar& Mehdizadeh, Mehdi. Neuroprotective Effects of Bone Marrow Mesenchymal Stem Cells on Bilateral Common Carotid Arteries Occlusion Model of Cerebral Ischemia in Rat. Behavioural Neurology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099435
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099435
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر