Modulation of Erythrocyte Plasma Membrane Redox System Activity by Curcumin
المؤلفون المشاركون
Kesharwani, Rajesh Kumar
Misra, Krishna
Singh, Prabhakar
Rizvi, Syed Ibrahim
المصدر
Biochemistry Research International
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Plasma membrane redox system (PMRS) is an electron transport chain system ubiquitously present throughout all cell types.
It transfers electron from intracellular substrates to extracellular acceptors for regulation of redox status.
Curcumin, isolated from Curcuma longa, has modulatory effects on cellular physiology due to its membrane interaction ability and antioxidant potential.
The present study investigates the effect of curcumin on PMRS activity of erythrocytes isolated from Wistar rats in vitro and in vivo and validated through an in silico docking simulation study using Molegro Virtual Docker (MVD).
Effects of curcumin were also evaluated on level of glutathione (GSH) and the oxidant potential of plasma measured in terms of plasma ferric equivalent oxidative potentials (PFEOP).
Results show that curcumin significantly ( p < 0.01 ) downregulated the PMRS activity in a dose-dependent manner.
Molecular docking results suggest that curcumin interacts with amino acids at the active site cavity of cytochrome b 5 reductase, a key constituent of PMRS.
Curcumin also increased the GSH level in erythrocytes and plasma while simultaneously decreasing the oxidant potential (PFEOP) of plasma.
Altered PMRS activity and redox status are associated with the pathophysiology of several health complications including aging and diabetes; hence, the above finding may explain part of the role of curcumin in health beneficial effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Singh, Prabhakar& Kesharwani, Rajesh Kumar& Misra, Krishna& Rizvi, Syed Ibrahim. 2016. Modulation of Erythrocyte Plasma Membrane Redox System Activity by Curcumin. Biochemistry Research International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099487
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Singh, Prabhakar…[et al.]. Modulation of Erythrocyte Plasma Membrane Redox System Activity by Curcumin. Biochemistry Research International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099487
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Singh, Prabhakar& Kesharwani, Rajesh Kumar& Misra, Krishna& Rizvi, Syed Ibrahim. Modulation of Erythrocyte Plasma Membrane Redox System Activity by Curcumin. Biochemistry Research International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099487
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099487
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر