Curcumin Mediated Attenuation of Carbofuran Induced Oxidative Stress in Rat Brain
المؤلفون المشاركون
Sharma, Bechan
Gupta, Vivek Kumar
Jaiswal, Sunil Kumar
Sharma, Ashish
Singh, Rakesh Kumar
المصدر
Biochemistry Research International
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-24
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
The indiscriminate use of carbofuran to improve crop productivity causes adverse effects in nontargets including mammalian systems.
The objective of this study was to evaluate carbofuran induced oxidative stress in rat brain stem and its attenuation by curcumin, a herbal product.
Out of 6 groups of rats, 2 groups received two different doses of carbofuran, that is, 15 and 30% of LD50, respectively, for 30 days.
Out of these, 2 groups receiving same doses of carbofuran were pretreated with curcumin (100 mg/kg body weight).
The levels of antioxidants, TBARS, GSH, SOD, catalase, and GST were determined in rat brain stem.
The 2 remaining groups served as placebo and curcumin treated, respectively.
The data suggested that carbofuran at different doses caused significant alterations in the levels of TBARS and GSH in dose dependent manner.
The TBARS and GSH contents were elevated.
The activities of SOD, catalase, and GST were significantly inhibited at both doses of carbofuran.
The ratio of P/A was also found to be sharply increased.
The pretreatment of curcumin exhibited significant protection from carbofuran induced toxicity.
The results suggested that carbofuran at sublethal doses was able to induce oxidative stress in rat brain which could be attenuated by curcumin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jaiswal, Sunil Kumar& Sharma, Ashish& Gupta, Vivek Kumar& Singh, Rakesh Kumar& Sharma, Bechan. 2016. Curcumin Mediated Attenuation of Carbofuran Induced Oxidative Stress in Rat Brain. Biochemistry Research International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099495
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jaiswal, Sunil Kumar…[et al.]. Curcumin Mediated Attenuation of Carbofuran Induced Oxidative Stress in Rat Brain. Biochemistry Research International No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099495
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jaiswal, Sunil Kumar& Sharma, Ashish& Gupta, Vivek Kumar& Singh, Rakesh Kumar& Sharma, Bechan. Curcumin Mediated Attenuation of Carbofuran Induced Oxidative Stress in Rat Brain. Biochemistry Research International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099495
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099495
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر