Esophageal Intramural Pseudodiverticulosis and Concomitant Eosinophilic Esophagitis: A Case Series

الملخص EN

Background.

Esophageal intramural pseudodiverticulosis (EIPD) is an idiopathic benign chronic disease characterized by flask-like outpouchings of the esophageal wall.

It is unknown whether there is a genuine association between EIPD and eosinophilic esophagitis (EoE).

Aims.

To investigate a possible relationship between EIPD and EoE.

Methods.

Patients with radiographic or endoscopic evidence of pseudodiverticulosis were identified from the database at a single academic center.

Cases were analyzed in three areas: clinical information, endoscopic findings, and course.

Results.

Sixteen cases of esophageal pseudodiverticulosis were identified.

Five patients had histologic evidence of eosinophilic esophagitis.

Patients with EoE had pseudodiverticula in the mid-to-distal esophagus while those with EIPD had pseudodiverticula predominantly in the proximal esophagus ( p < 0.001 ).

EoE with pseudodiverticulosis occurred in younger patients ( p < 0.019 ).

Food bolus obstructions were more common in patients with EoE and pseudodiverticulosis than in EIPD ( p < 0.034 ).

Conclusions.

This is the first case series supporting a potential association between EoE and pseudodiverticulosis.

We also identify characteristic features of pseudodiverticulosis that may raise clinical suspicion of underlying eosinophilic esophagitis.