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Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease
المؤلفون المشاركون
Delladetsima, I.
Ladas, Spiros D.
Papatheodoridis, George V.
Vlachogiannakos, Jiannis
Daikos, George
Gizis, Michalis
Laoudi, Eyfrosyni
Koutsounas, Ioannis
Kaltsa, Garyfallia
Vafiadis-Zouboulis, Irene
Siakavellas, Spyros I.
Bamias, Giorgos
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-09
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory function and is overexpressed in neoplastic and inflammatory conditions.
Serum DcR3 (sDcR3) levels during the chronic hepatitis/cirrhosis/hepatocellular carcinoma (HCC) sequence have not been explored.
Objective.
To assess the levels and significance of sDcR3 protein in various stages of chronic liver disease.
Methods.
We compared sDcR3 levels between healthy controls and patients with chronic viral hepatitis (CVH), decompensated cirrhosis (DC), and HCC.
Correlations between sDcR3 levels and various patient- and disease-related factors were analyzed.
Results.
sDcR3 levels were significantly higher in patients with CVH than in controls (P<0.01).
sDcR3 levels were elevated in DC and HCC, being significantly higher compared not only to controls (P<0.001 for both) but to CVH patients as well (P<0.001 for both).
In addition, DcR3 protein was detected in large quantities in the ascitic fluid of cirrhotics.
In patients with CVH, sDcR3 significantly correlated to fibrosis severity, as estimated by Ishak score (P=0.019) or by liver stiffness measured with elastography (Spearman r=0.698, P<0.001).
In cirrhotic patients, significant positive correlations were observed between sDcR3 levels and markers of severity of hepatic impairment, including MELD score (r=0.653, P<0.001).
Conclusions.
Circulating levels of DcR3 are elevated during chronic liver disease and correlate with severity of liver damage.
sDcR3 may serve as marker for liver fibrosis severity and progression to end-stage liver disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bamias, Giorgos& Gizis, Michalis& Delladetsima, I.& Laoudi, Eyfrosyni& Siakavellas, Spyros I.& Koutsounas, Ioannis…[et al.]. 2016. Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099857
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bamias, Giorgos…[et al.]. Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099857
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bamias, Giorgos& Gizis, Michalis& Delladetsima, I.& Laoudi, Eyfrosyni& Siakavellas, Spyros I.& Koutsounas, Ioannis…[et al.]. Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099857
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099857
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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