A Canadian Study toward Changing Local Practice in the Diagnosis of Pediatric Celiac Disease
المؤلفون المشاركون
Rajani, Seema
Huynh, Hien Q.
Shirton, Leanne
Kluthe, Cheryl
Spady, Donald
Prosser, Connie
Meddings, Jon
Rempel, Gwen R.
Persad, Rabindranath
Turner, Justine M.
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-26
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The European Society for Pediatric Gastroenterology, Hepatology and Nutrition endorses serological diagnosis (SD) for pediatric celiac disease (CD).
The objective of this study was to pilot SD and to prospectively evaluate gastrointestinal permeability and mucosal inflammation at diagnosis and after one year on the gluten-free diet (GFD).
We hypothesized that SD would be associated with similar short term outcomes as ED.
Method.
Children, 3–17 years of age, referred for possible CD were eligible for SD given aTTG level ≥200 U/mL, confirmed by repeat aTTG and HLA haplotypes.
Gastrointestinal permeability, assessed using sugar probes, and inflammation, assessed using fecal calprotectin (FC), at baseline and after one year on a GFD were compared to patients who had ED.
Results.
Enrolled SD ( n = 40 ) and ED ( n = 48 ) patients had similar demographics.
ED and SD groups were not different in baseline lactulose: mannitol ratio (L : M) (0.049 versus 0.034; p = 0.07 ), fractional excretion of sucrose (%FES; 0.086 versus 0.092; p = 0.44 ), or fecal calprotectin (FC; 89.6 versus 51.4; p = 0.05 ).
At follow-up, urine permeability improved and was similar between groups, L : M (0.022 versus 0.025; p = 0.55 ) and %FES (0.040 versus 0.047; p = 0.87 ) ( p > 0.05 ).
FC improved but remained higher in the SD group (37.1 versus 15.9; p = 0.04 ).
Conclusion.
Patients on the GFD showed improved intestinal permeability and mucosal inflammation regardless of diagnostic strategy.
This prospective study supports that children diagnosed by SD have resolving mucosal disease early after commencing a GFD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rajani, Seema& Huynh, Hien Q.& Shirton, Leanne& Kluthe, Cheryl& Spady, Donald& Prosser, Connie…[et al.]. 2016. A Canadian Study toward Changing Local Practice in the Diagnosis of Pediatric Celiac Disease. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099900
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rajani, Seema…[et al.]. A Canadian Study toward Changing Local Practice in the Diagnosis of Pediatric Celiac Disease. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1099900
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rajani, Seema& Huynh, Hien Q.& Shirton, Leanne& Kluthe, Cheryl& Spady, Donald& Prosser, Connie…[et al.]. A Canadian Study toward Changing Local Practice in the Diagnosis of Pediatric Celiac Disease. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1099900
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099900
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر