Effectiveness of Second through Sixth Line Salvage Helicobacter pylori Treatment: Bismuth Quadruple Therapy is Almost Always a Reasonable Choice
المؤلفون المشاركون
Shaikh, Tahir
Fallone, Carlo A.
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-03-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Aim.
There is a paucity of data on the efficacy of empiric H.
pylori treatment after multiple treatment failures.
The aim of this study is to examine the efficacy of empiric salvage therapy as a second through sixth line treatment.
Methods.
In this single gastroenterology center prospective study in Montreal, Canada, patients with failed H.
pylori treatment were offered empiric salvage therapy based on the patients’ previous antibiotic exposure.
Enrollment occurred after 1–5 previous failed attempts and eradication determined at least 4 weeks after completion of treatment.
Results.
205 treatments were attempted in 175 patients using 7 different regimens.
Eradication was achieved in 154 attempts (PP = 81% (154/191), ITT = 75% (154/205)).
Bismuth quadruple therapy (BQT) had higher eradication success (PP = 91% (102/112), ITT = 84% (102/121)) when compared to all PPI triple therapies combined (PP = 66% (49/74), absolute risk reduction (ARR): 25% (95% CI: 13–37), ITT = 62% (49/79), ARR: 22% (95% CI: 10–35), and p < 0.001 ) and when compared to levofloxacin triple therapy (PP = 66% (40/61), ARR: 26% (95% CI: 13–39), ITT = 61% (40/66), and ARR: 24% (95% CI: 10–37)).
Eradication was achieved in a high proportion with BQT on attempt two (PP = 94% (67/71), ITT = 91% (67/74)), three (PP = 85% (17/20), ITT = 71% (17/24)), four (PP = 100% (11/11), ITT = 92% (11/12)), and five (PP = 86% (6/7), ITT = 75% (6/8)).
Patients with previous combined bismuth and tetracycline exposure had a lower proportion of eradication compared to patients without such an exposure (PP: 60% (6/10) versus 95% (94/99), ARR: 35% (95% CI: 11–64), and p < 0.001 ; ITT: 55% (6/11) versus 90% (94/105), ARR: 35% (95% CI: 10–62), and p < 0.01 ).
Conclusions.
Salvage therapy with a bismuth quadruple regimen is superior to triple therapies and is effective for second through fifth line empirical treatment (≥85% PP, ≥70% ITT).
Successful eradication is significantly lower with BQT if a similar bismuth based regimen was used in the past.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shaikh, Tahir& Fallone, Carlo A.. 2016. Effectiveness of Second through Sixth Line Salvage Helicobacter pylori Treatment: Bismuth Quadruple Therapy is Almost Always a Reasonable Choice. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shaikh, Tahir& Fallone, Carlo A.. Effectiveness of Second through Sixth Line Salvage Helicobacter pylori Treatment: Bismuth Quadruple Therapy is Almost Always a Reasonable Choice. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1099915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shaikh, Tahir& Fallone, Carlo A.. Effectiveness of Second through Sixth Line Salvage Helicobacter pylori Treatment: Bismuth Quadruple Therapy is Almost Always a Reasonable Choice. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1099915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر