Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials
المؤلفون المشاركون
McNabb-Baltar, Julia
Yaghoobi, Mohammad
Bijarchi, Raheleh
Cotton, Peter B.
المصدر
Canadian Journal of Gastroenterology and Hepatology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Pancreatic enzyme supplementation is widely used to treat pain in patients with chronic pancreatitis, despite little evidence for efficacy.
We performed a systematic review of the literature and a meta-analysis to investigate its effectiveness.
Methods.
All randomized controlled parallel or crossover trials in patients with chronic pancreatitis comparing pancreatic enzyme supplementation to placebo were included.
The main outcome was improvement in pain score or reduced analgesic consumption.
Two independent reviewers extracted data.
Mantel-Haenszel random effect model meta-analysis was used whenever methodologically appropriate.
Results.
Five out of 434 retrieved studies were included in the systematic review.
All studies used relatively similar methodology.
Four studies using enteric-coated pancreatic enzyme supplementation failed to show any improvement in pain as compared to placebo.
The only study using non-enteric-coated enzymes did show reduction in the pain score.
There was significant heterogeneity among studies in both analyses.
Random model meta-analysis of three studies showed no significant difference in the mean of daily pain score (mean difference: 0.09 (1.57–1.39), p=0.91) or average weekly analgesic consumption (mean difference: −0.30 (−2.37–1.77), p=0.77) between the periods of administering pancreatic enzyme supplementation versus placebo.
Conclusion.
Pancreatic enzyme supplements do not seem to relieve abdominal pain in patients with chronic pancreatitis and should not be prescribed solely for this purpose, given their significant cost and potential side effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yaghoobi, Mohammad& McNabb-Baltar, Julia& Bijarchi, Raheleh& Cotton, Peter B.. 2016. Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Canadian Journal of Gastroenterology and Hepatology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099939
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yaghoobi, Mohammad…[et al.]. Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Canadian Journal of Gastroenterology and Hepatology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1099939
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yaghoobi, Mohammad& McNabb-Baltar, Julia& Bijarchi, Raheleh& Cotton, Peter B.. Pancreatic Enzyme Supplements Are Not Effective for Relieving Abdominal Pain in Patients with Chronic Pancreatitis: Meta-Analysis and Systematic Review of Randomized Controlled Trials. Canadian Journal of Gastroenterology and Hepatology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1099939
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099939
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر