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Clinical and Laboratory Diagnosis of Buruli Ulcer Disease: A Systematic Review
المؤلفون المشاركون
Sakyi, Samuel A.
Aboagye, Samuel Y.
Darko Otchere, Isaac
Yeboah-Manu, Dorothy
المصدر
Canadian Journal of Infectious Diseases and Medical Microbiology
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Buruli ulcer (BU) is a necrotizing cutaneous infection caused by Mycobacterium ulcerans.
Early diagnosis is crucial to prevent morbid effects and misuse of drugs.
We review developments in laboratory diagnosis of BU, discuss limitations of available diagnostic methods, and give a perspective on the potential of using aptamers as point-of-care.
Methods.
Information for this review was searched through PubMed, web of knowledge, and identified data up to December 2015.
References from relevant articles and reports from WHO Annual Meeting of the Global Buruli Ulcer initiative were also used.
Finally, 59 articles were used.
Results.
The main laboratory methods for BU diagnosis are microscopy, culture, PCR, and histopathology.
Microscopy and PCR are used routinely for diagnosis.
PCR targeting IS2404 is the gold standard for laboratory confirmation.
Culture remains the only method that detects viable bacilli, used for diagnosing relapse and accrued isolates for epidemiological investigation as well as monitoring drug resistance.
Laboratory confirmation is done at centers distant from endemic communities reducing confirmation to a quality assurance.
Conclusions.
Current efforts aimed at developing point-of-care diagnostics are saddled with major drawbacks; we, however, postulate that selection of aptamers against MU target can be used as point of care.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sakyi, Samuel A.& Aboagye, Samuel Y.& Darko Otchere, Isaac& Yeboah-Manu, Dorothy. 2016. Clinical and Laboratory Diagnosis of Buruli Ulcer Disease: A Systematic Review. Canadian Journal of Infectious Diseases and Medical Microbiology،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099996
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sakyi, Samuel A.…[et al.]. Clinical and Laboratory Diagnosis of Buruli Ulcer Disease: A Systematic Review. Canadian Journal of Infectious Diseases and Medical Microbiology No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1099996
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sakyi, Samuel A.& Aboagye, Samuel Y.& Darko Otchere, Isaac& Yeboah-Manu, Dorothy. Clinical and Laboratory Diagnosis of Buruli Ulcer Disease: A Systematic Review. Canadian Journal of Infectious Diseases and Medical Microbiology. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1099996
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1099996
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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